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EC number: 209-247-0 | CAS number: 563-41-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 November 2017 - 24 August 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 55507861
- Expiration date of the lot/batch: 28 April 2019
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Room temperature (15 to 25°C), dark - Analytical monitoring:
- yes
- Details on sampling:
- The samples, of nominal concentration 1 g/L, were incubated at 50°C in the dark until sampling was required (immediately, and then after 2.4, 70 (pH 4 and pH 7 only) and
120 hours).
At each sampling time, two samples were removed from the bath and an aliquot (100 μL) of each was diluted to volume (20 mL) with methanol. A portion (1 mL) of the resultant solution was then diluted to 10 mL with methanol for analysis by liquid chromatography-mass spectrometry (LC-MS).
Sample pH and incubation temperature were monitored over the period of the test. - Buffers:
- Buffer solutions were prepared as follows:
pH 4: 0.2M aqueous potassium dihydrogen orthophosphate (220 mL) was mixed with
0.07M aqueous disodium hydrogen orthophosphate dodecahydrate (500 mL) and purified water (1280 mL). The pH was adjusted to 4.0 ± 0.05 with orthophosphoric acid.
pH 7:0.2M aqueous potassium dihydrogen orthophosphate (500 mL) was mixed with
1M sodium hydroxide (60 mL) and purified water (1440 mL). The pH was adjusted to
7.0 ± 0.05 with 1M hydrochloric acid or 1M sodium hydroxide, as required.
pH 9: 0.2M aqueous tris(hydroxymethyl)aminomethane (100 mL) was mixed with
0.2M hydrochloric acid (10 mL) and purified water (290 mL). The pH was adjusted to
9.0 ± 0.05 with 1M hydrochloric acid. - Details on test conditions:
- Tests were carried out using reagent grade chemicals, purified sterile water and sterilised glassware.
- Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 1 254 - <= 1 311 mg/L
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 1 135 - <= 1 200
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 1 069 - <= 1 100
- Number of replicates:
- 2
- Positive controls:
- no
- Negative controls:
- no
- Preliminary study:
- The preliminary study showed that at each of pH 4, 7 and 9 and 50 ± 0.5ºC, less than 10% hydrolysis had occurred after 120 hours (5 days), equivalent to a half-life of greater than
1 year under environmental conditions (25°C). No further testing was considered necessary. - Transformation products:
- no
- % Recovery:
- > 90
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 5 d
- % Recovery:
- > 90
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 5 d
- % Recovery:
- > 90
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- hydrolytically stable based on preliminary test
- Details on results:
- The preliminary study showed that at each of pH 4, 7 and 9 and 50 0.5ºC, less than 10% hydrolysis had occurred after 120 hours (5 days), equivalent to a half-life of greater than
1 year under environmental conditions (25°C). No further testing was considered necessary. - Validity criteria fulfilled:
- yes
- Conclusions:
- Semicarbazide Hydrochloride was determined to be hydrolytically stable under acidic, neutral and basic conditions.
Reference
Description of key information
Semicarbazide Hydrochloridewas determined to be hydrolytically stable under acidic, neutral and basic conditions.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 25 °C
Additional information
The half-life of greater than 1 year under environmental conditions (25°C). Value of 1 year is used for the risk assessment.
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