Glycine, N, N' - (1,9-nonandeiyl) bis-, monopotasium salt

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

(Q)SAR

Adequacy of study:

key study

Study period:

2019

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Qualifier:

according to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

GLP compliance:

no

Test organisms (species):

Daphnia magna

Test type:

static

Water media type:

freshwater

Total exposure duration:

48 h

Key result

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

141.25 mg/L

Nominal / measured:

estimated

Conc. based on:

not specified

Basis for effect:

mortality

The estimated value for Potassium Azeloyl Diglycinate after applying the ProtoQSAR model for acute aquatic toxicity in daphnia was 141.25 mg/L. Furthermore, the compound falls inside the applicability domain of the model.

Validity criteria fulfilled:

yes

Conclusions:

ProtoQSAR model for acute aquatic toxicity in daphnia estimated for Potassium Azeloyl Diglycinate an acute 48h EC50 to daphnia of 141.25 mg/L. The prediction, falls inside the applicability domain of the model and is considered reliable. Furthermore, and based on the Globally Harmonized System of Classification and Labelling (CLP/GHS) , the test compound is considerd non-toxic / non-harmful. 173.78 mg/L > 100.

Executive summary:

Regulatory purpose: This study was designed to generate estimated in silico (nontesting) data for acute aquatic toxicity in daphnia for Potassium Azeloyl Diglycinate to be used in the regulatory framework of REACH. EC50 = 141.25 mg/L

On the basis of EC 50 value it is concluded that this test chemical is considered to be not classified according to CLP classification criteria.

Description of key information

The acute aquatic toxicity in daphnia (EC50; 48 hours) (OECD 202) of Potassium Azeloyl Diglycinate was estimated using the ProtoQSAR QSAR model. The estimated value was 141.25 mg/L. The prediction, falls inside the applicability domain of the model and is considered reliable. Furthermore, and based on the Globally Harmonized System of Classification and Labelling (CLP/GHS) , the test compound is considerd non-toxic / non-harmful. 141.25mg/L > 100. On the basis of EC 50 value it is concluded that this test chemical is considered to be not classified according to CLP classification criteria.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

141.25 mg/L