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Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Description of key information

For acute toxicity (EC50) in algae, VEGA/ProtoQSAR classification model predicts the compound as“NON-Toxic” (i.e. LC50 > 10 mg/l), associated to low reliability. Similarly, VEGA/ProtoQSAR regression model provides prediction of 128.59 mg/l, thus resulting in agreement with VEGA/ProtoQSAR classification model (ADI = 0.355). However, both models reports experimental value as “toxic” for the most similar compound with SMILES N#CC=CC(F)(F)F. The toxicity of such
compound may be triggered by the triple bond N#C, not present in the target compound. In any case, we cannot exclude a toxicity for the target compound based on read-across considerations.
Overall assessment. The predictions for acute toxicity in algae are consistent among each other, although low reliability is associated to both predictions and they are not supported by read-across considerations. The compound of concernmay be not toxicto algae (LC50 > 100 mg/l) but with a high uncertainty.

Key value for chemical safety assessment

EC50 for freshwater algae:
128.59 mg/L

Additional information