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EC number: 245-327-1 | CAS number: 22919-56-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 1996
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- As Octanoic acid, compound with 2,2',2''-nitrilotriethanol (1:1) is highly soluble in water, and is expected to readily dissociate into Triethanolamine and Octanoic acid in the aquatic environment, it is considered appropriate to read across from Octanoic acid and Triethanolamine. Triethanolamine experimental data is from a peer reviewed scientific journal.
Data source
Reference
- Reference Type:
- publication
- Title:
- Biodegradation of triethanolamine.
- Author:
- West RJ and Gonsior SJ
- Year:
- 1 996
- Bibliographic source:
- Environ Toxicol Chem 15(4): 472-480.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- CO2 evolution test
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,2',2''-nitrilotriethanol
- EC Number:
- 203-049-8
- EC Name:
- 2,2',2''-nitrilotriethanol
- Cas Number:
- 102-71-6
- Molecular formula:
- C6H15NO3
- IUPAC Name:
- 2,2',2''-nitrilotriethanol
- Test material form:
- liquid
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- other: Mixed liquor activated sludge (secondary effluent)
- Details on inoculum:
- Mixed liquor activated sludge (secondary effluent) was collected from the West Bay County Wastewater Treatment Plant, Bay City, Michigan, on December 17, 1991. This facility represented a typical municipal activated sludge process treating a daily flow of between 3 and 4 million gallons of primarily municipal (.90% v/v) sewage. Influent BOD loadings averaged between 150 and 200 mg/L, with mixed liquor suspended solids (MLSS) maintained on the order of 1,500 mg/L. A consolidated mixed liquor sample was collected just prior to secondary clarification. The sample was aerated in the laboratory for approximately 22 h to provide for removal of residual dissolved organic substrates. The mixed liquor was used in its collected state and diluted to achieve desired MLSS levels in the experimental reaction mixtures.
- Duration of test (contact time):
- ca. 6 d
Initial test substance concentration
- Initial conc.:
- > 600 - < 5 700 µg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- ‘Biodegradation of TEA was examined in a series of reaction mixtures containing combinations of 600 or 5,700 μg/L TEA and 164 or 818 mg/L MLSS in a minimal salts basal medium. Duplicate reactions containing each combination of test material and mixed liquor solids concentrations were prepared in 500-ml polypropylene Erlenmeyer flasks. Single biologically inhibited control reactions were prepared or each configuration to measure potential abiotic losses of TEA. These were prepared in a manner similar to the viable reactions, with the exception that formaldehyde was incorporated at a final concentration of 2.8% (w/v). All reactions were amended with [14C]TEA to yield approximately 0.7 μCi/ml reaction solution. The specific activity of the [14C]TEA was adjusted with concentrated aqueous TEA solution to yield the desired total concentrations of test material. The reaction flasks were sealed using rubber stoppers fitted with 16 x 150-mm glass tubular CO2 traps containing 4 ml of a 1 N KOH solution. These traps consisted of capped culture tubes with openings cut near the bottom to allow headspace gas contact with the trap solution as the reaction mixtures were agitated. The activated sludge reactions were incubated in darkness at 25°C, with agitation provided at 125 rpm on a gyratory shaker’.
Results and discussion
% Degradationopen allclose all
- Parameter:
- % degradation (test mat. analysis)
- Value:
- 100
- Sampling time:
- 5 d
- Remarks on result:
- other: Primary biodegradation of 5.7 mg/L (38.2 μmol/L) TEA in a test with 164 mg/l municipal activated sludge.
- Parameter:
- % degradation (test mat. analysis)
- Value:
- ca. 100
- Sampling time:
- 1 d
- Remarks on result:
- other: Primary biodegradation of 0.6 mg/L (4.02 μmol/L) TEA in a test with 164 mg/l municipal activated sludge.
Any other information on results incl. tables
Summary of TEA primary biodegradation adn mineraliztion in various environmental matrices (West & Gonsior, 1996):
Activated sludge(mg/L MLSS) |
TEA Concen. (μmol/L) |
TEA concen. (mg/L) |
Biodegradation rate constant (/d) |
Biodegradationhalf-life (d) |
Mineraliation rate constant (/d) |
Mineralisation half-life (d) |
CO2/ThCO2(%) |
164 |
4.0 |
0.6 |
6.86 |
0.1 |
1.92 |
0.36 |
56 ± 10 |
164 |
38.2 |
5.7 |
1.36 |
0.51 |
1.04 |
0.67 |
54 ± 3 |
818 |
4.0 |
0.6 |
30 |
0.02 |
2.86 |
0.24 |
55 ± 1 |
818 |
38.2 |
5.7 |
6.7 |
0.01 |
1.69 |
0.41 |
52 ± 0 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- It can be concluded from the results of this experimetnal study that triethanolamine is readily biodegradable.
- Executive summary:
As Octanoic acid, compound with 2,2',2''-nitrilotriethanol (1:1) is expected to readily dissociate into Triethanolamine and Octanoic acid in the aquatic environment, which is supported by its very high water solubility, it is considered appropriate to read across from Triethanolamine.
The biodegradability of Triethanolamine was assessed in a study conducted by West & Gonsior (1996), this study was assigned a reliability score of 2 in accordance with the criteria for assessing data quality set forth by Klimischet al.(1997) as study is well documented and meets generally accepted scientific procedures.
Biodegradability was assessed in CO2 evolution study using mixed liquor activated sludge in a series of reaction mixtures containing combinations of 600 or 5700 μg/L and 164 or 818 mg/L mixed liquor suspended solids. Measurements were achieved by used radiolabelled Triethanolamine. Under the conditions of this study, Triethanolamine was found to readily biodegradable.
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