Registration Dossier
Registration Dossier
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EC number: 429-040-0 | CAS number: 272460-97-6
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 2 005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD [C(99) 186 (Final)]
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 429-040-0
- EC Name:
- -
- Cas Number:
- 272460-97-6
- Molecular formula:
- C30H26O4S2
- IUPAC Name:
- 1-{4-[(4-benzoylphenyl)sulfanyl]phenyl}-2-methyl-2-(4-methylbenzenesulfonyl)propan-1-one
- Test material form:
- solid
- Details on test material:
- Nature of substance: ESACURE 1001
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Amount / concentration applied:
- 100 mg
- Number of animals or in vitro replicates:
- 9
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Score:
- ca. 2.77
- Max. score:
- 3
- Remarks on result:
- other: Max. duration: h; Max. value at end of observation period: 3
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Score:
- ca. 2.66
- Max. score:
- 3
- Remarks on result:
- other: Max. duration: h; Max. value at end of observation period: 2
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.27
- Max. score:
- 3
- Remarks on result:
- other: Max. duration: h; Max. value at end of observation period: 2
- Irritation parameter:
- iris score
- Basis:
- mean
- Score:
- 1.22
- Max. score:
- 2
- Remarks on result:
- other: Max. duration: h; Max. value at end of observation period: 2
- Irritant / corrosive response data:
- Reversibility of any observed effect: Changes fully reversible within 7 days
- Other effects:
- In the group of six rabbits, notable occular changes consisting of conjunctival redness and chemosis, iris congestion and corneal opacity were noted up to 72 hours - 7 days after exposure.
Thre native animals were trated at the same dose of 0.1 of test article, but eyes were washed at 2-3 mins after application, then observed and scored as for the previous six animals. Slight ocular changes, confined to conjunctival redness were noted up to 24 hours after exposure.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
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