Registration Dossier

Administrative data

Endpoint:
flash point of flammable liquids
Type of information:
experimental study
Adequacy of study:
key study
Study period:
07 March - 17 September 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report Date:
2018

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
EU Method A.9 (Flash-Point)
Deviations:
no
Qualifier:
according to
Guideline:
ISO 2719 (Determination of flash point - Pensky-Martens closed cup method)
Deviations:
no
Qualifier:
according to
Guideline:
ASTM D93 (Standard test methods for flash point by pensky-martens closed cup tester)
Deviations:
no
Qualifier:
according to
Guideline:
other: ASTM D7094: “Standard Test Method for Flash Point by Modified Continuously Closed Cup (MCCCFP) Tester”
Deviations:
no
Qualifier:
according to
Guideline:
other: UN no. ST/SG/AC.10/11/Rev.6: “Non-Viscous Flammable Liquids”
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
closed cup
Flash point apparatus:
other: Euraflash flash-point tester (Eralytics, Vienna, Austria)

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study reports): JNJ-42398681-AAA (T001589)
- Physical state: liquid
- Appearence: light brown
Specific details on test material used for the study:
- Batch n°: I16FB3011
- Analytical purity: 87%
- Expiration date: 14 March 2018
- Storage condition: at room temperature

Results and discussion

Flash point
Key result
Flash point:
133 °C
Atm. press.:
1 013.25 hPa
Remarks on result:
other: The flash-point is automatically corrected for atmospheric pressure by the flash point tester

Any other information on results incl. tables

Preliminary test

The test cup was heated at a rate of 5± 0.5°C/minute. Starting at 25°C, an attempt was made to ignite the vapour of the test item for every 2°C temperature rise.

No flash-point was observed below the boiling temperature of the test item (i.e. 197°C). Therefore the preliminary test was repeated. The temperature of the test item at the start of the additional test was 25.0°C. Starting at 25°C the ignition source was applied for every 2°C temperature rise. A third preliminary study was carried out to confirm the result of either the first of the second preliminary test.

Main study

Three tests were performed according to the ISO Guide 2719 method. The test cup was heated at a rate of 5±0.5°C/minute. Starting at 108°C, ignition was tested for every 2°C temperature rise.

The result of the first test was > 28°C from the starting temperature of the ignition source. Two more tests were performed. In these tests, the temperature of the test item at the start of the additional test was 115°C. Starting at 115°C, ignition was tested for every 2°C temperature rise.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The closed cup method was applied for the determination of the flash-point of JNJ-42398681-AAA (T001589)

The flash-point of the test item was 133°C.