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Physical & Chemical properties

Water solubility

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Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
07 March - 16 September 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report Date:
2018

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
flask method

Test material

Reference
Name:
Unnamed
Test material form:
liquid
Details on test material:
Physical state: liquid
Appearence: light brown liquid
Specific details on test material used for the study:
- Batch n°: I16FB3013
- Analytical purity: 87.5%
- Expiration date: 07 June 2018
- Storage condition: at room temperature

Results and discussion

Water solubility
Key result
Water solubility:
0.535 g/L
Conc. based on:
test mat. (dissolved fraction)
Remarks:
concentration analysed after centrifugation
Loading of aqueous phase:
1.548 g/L
Incubation duration:
>= 24 - <= 72 h
Temp.:
20 °C
pH:
>= 7.1 - <= 7.2
Details on results:
Preliminary test
The content of test item dissolved in the water sample was 0.279 g/L.

Main test
The results for the samples taken at 24, 48 and 72 hours are given in the table in the next section. The maximum difference (MD) of the concentrations determined in the 24, 48 and 72 hour test samples was ≤ 15%. Based on this, the water solubility of the test item is given as the mean value of the analysed concentrations.
The centrifugation method was not checked. As the maximum difference between the different stirring times was 3.77%, it was considered that the obtained values were not biased by the presence of undissolved test item. A random event as insufficient centrifugation would increase variation between the results of analysis, which was not observed. The integrity of the study was, therefore, not affected.
A small response at the retention time of the test item was detected in the chromatogram of the pretreated blank mixture. The maximum contribution to the samples was 0.044%. It was considered that it has no significant effect on the results of the test samples.

Any other information on results incl. tables

The results for the samples taken at 24, 48 and 72 hours are given in the table underneath.

 Stirring time (hours) Analysed concentration (g/L)   Mean (g/L)  Maximum Difference (MD) (%)  pH
 24  0.522 0.535  3.77  7.1
 48  0.540      7.1
 72  0.542      7.2

Applicant's summary and conclusion

Conclusions:
The flask method was applied for the determination of the water solubility of JNJ-42819543-AAA (T001596).
The water solubility of the test item at 20°C was 0.535 g/L.
The pH of the aqueous samples was 7.1 and 7.2.