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EC number: 824-458-3 | CAS number: 1263679-68-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
A single Local Lymph Node Assay (LLNA) has been performed using HCFO-1233yd(Z)
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13/09/2018 - 07/11/2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 442B (Skin Sensitization: Local Lymph Node Assay: BrdU-ELISA)
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- mouse local lymph node assay (LLNA): BrdU-ELISA
- Species:
- mouse
- Strain:
- CBA:J
- Sex:
- female
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- Test substance dissolved into vehicle at a concentration of 50%
- No. of animals per dose:
- 4
- Positive control substance(s):
- hexyl cinnamic aldehyde (CAS No 101-86-0)
- Statistics:
- None conducted.
- Key result
- Parameter:
- SI
- Value:
- 1.1
- Variability:
- 0.07
- Test group / Remarks:
- 25.0% concentration group
- Key result
- Parameter:
- SI
- Value:
- 1
- Variability:
- 0.09
- Test group / Remarks:
- 50.0% concentration group
- Key result
- Parameter:
- SI
- Value:
- 92.1
- Variability:
- 0.08
- Test group / Remarks:
- 92.1% concentration group
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Consequently, the SI's for the 92.1%, 50.0 and 25.0 w/v% were 1.10, 1.00 and 1.10: all the Sis were less than 1.6. Therefore, under the conditions tested, HCFO-1233yd(Z) was considered to be a non-sensitizer.
- Executive summary:
Local lymph node assay: BrdU-ELISA was performed in accordance with the OECD TG 442B using female CBA/J mice, and the skin sensitization potential of HCFO-1233yd(Z) was assessed by calculating the stimulation index (SI).
In the pre-screen test, 92.1 %, 50.0 and 25.0 w/v% of test substance formulations, prepared with acetone: olive oil (4:1, v/v: AOO), were applied to the dorsum of both ears of one animal/dose level once daily for 3 consecutive days. Clinical observations, body weight measurements and ear thickness measurements were performed. As a result, no abnormal changes which suggested excessive irritation or systemic toxicity were detected. Thus, the dose levels of the main study were set at 92.1 %, 50.0 and 25.0 w/v%.
In the main study, in addition to the test substance groups, vehicle control group which was applied with AOO and positive control group which was applied with 25.0 w/v% ahexylcinnamaldehyde (HCA) were set. The vehicle, HCA and test substance formulations were applied to the dorsum of both ears of 4 animals/group once daily for 3 consecutive days. Clinical observations and body weight measurements were performed. Approximately 48 hours after the final sensitization, 5-bromo-2'deoxyuridine (BrdU) was administered. Approximately 24 hours later, auricular lymph nodes were collected, the BrdU uptake levels were measured by ELISA, and the Sis were calculated. During the main study, no abnormal changes which suggested excessive irritation or systemic toxicity were noted. Therefore, all the data obtained were used to the skin sensitization evaluation.
Consequently, the Sis for the 92.1%, 50.0 and 25.0 w/v% were 1.10, 1.00 and 1.10: all the Sis were less than 1.6. Therefore, under the conditions tested, HCFO-1233yd(Z) was considered to be a non-sensitizer.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
BrdU-ELISA was performed in accordance with the OECD TG 442B using female CBA/J mice, and the skin sensitization potential of HCFO-1233yd(Z) was assessed by calculating the stimulation index (SI).
In the pre-screen test, 92.1 %, 50.0 and 25.0 w/v% of test substance formulations, prepared with acetone: olive oil (4:1, v/v: AOO), were applied to the dorsum of both ears of one animal/dose level once daily for 3 consecutive days. Clinical observations, body weight measurements and ear thickness measurements were performed. As a result, no abnormal changes which suggested excessive irritation or systemic toxicity were detected. Thus, the dose levels of the main study were set at 92.1 %, 50.0 and 25.0 w/v%.
In the main study, in addition to the test substance groups, vehicle control group which was applied with AOO and positive control group which was applied with 25.0 w/v% ahexylcinnamaldehyde (HCA) were set. The vehicle, HCA and test substance formulations were applied to the dorsum of both ears of 4 animals/group once daily for 3 consecutive days. Clinical observations and body weight measurements were performed. Approximately 48 hours after the final sensitization, 5-bromo-2'deoxyuridine (BrdU) was administered. Approximately 24 hours later, auricular lymph nodes were collected, the BrdU uptake levels were measured by ELISA, and the Sis were calculated. During the main study, no abnormal changes which suggested excessive irritation or systemic toxicity were noted. Therefore, all the data obtained were used to the skin sensitization evaluation.
Consequently, the Sis for the 92.1%, 50.0 and 25.0 w/v% were 1.10, 1.00 and 1.10: all the Sis were less than 1.6. Therefore, under the conditions tested, HCFO-1233yd(Z) was considered to be a non-sensitizer.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The available data indicates that classification for both skin sensitisation is not warranted.
HCFO-1233yd(Z) is not classified according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008 or UN Globally Harmonized System of Classification and Labelling of Chemicals (GHS).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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