Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 948-021-2 | CAS number: -
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1972-11-01
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- study conducted before the implementation of GLP
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Absolute of Jasmine (Jasminum grandiflorum) obtained from Jasmine concrete by ethanol extraction
- EC Number:
- 948-021-2
- Molecular formula:
- n.a.
- IUPAC Name:
- Absolute of Jasmine (Jasminum grandiflorum) obtained from Jasmine concrete by ethanol extraction
Constituent 1
- Specific details on test material used for the study:
- - Sample marking: RIFM 72-174
- Name: Jasmine Absolute
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- n.a.
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- n.a.
- Duration of exposure:
- 14 days
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 6 rabbits
- Control animals:
- no
- Details on study design:
- n.a.
- Statistics:
- n.a.
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality observed
- Clinical signs:
- other: No treatment related changes observed
- Gross pathology:
- n.a.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In conclusion, the dermal LD50 in rabbits after treatment with the test item is considered to be greater than 5000 mg/kg bw.
- Executive summary:
In an acute dermal toxicity study conducted similar to OECD 402, six rabbits were given dermally a single dose of the test item Jasmin absolute of 5000 mg/kg bw. The animals were observed for a total of 14 days. No mortality occurred during the observation period and no adverse signs of toxicity were recorded. In conclusion, the dermal LD50 in rats after treatment with the test item is greater than 5000 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
