Registration Dossier
Registration Dossier
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EC number: 219-774-8 | CAS number: 2528-39-4
Endpoint summary
Administrative data
Description of key information
Additional information
Acute toxicity studies evaluating the toxicity of the substance to aquatic organisms are available for four different trophic levels. All studies were performed according to international guidelines and GLP. The test substance was Trihexyl phosphate (CAS 2528-39-4). The water flea (Daphnia magna) turned out to be the most sensitive species with an EC50 (48 h) of 76 µg/L (LAUS GmbH, 2017d) followed by Desmodesmus subspicatus with an ErC50 (72 h) of 160 µg/L and ErC10 (72 h) of 95 µg/L (LAUS GmbH, 2017e) and Danio rerio with a LC50 (96 h) >100 µg/L (LAUS GmbH, 2017c). Since a reduction of the test item was observed in the aquatic test systems of algae, daphnia and fish over the test period all toxicological endpoints were evaluated based on the geometric mean of each test item concentration.
The substance did not cause inhibition of activated sludge up to and including 1000 mg/L, following the OECD guideline 209. Furthermore the substance did not cause inhibition of biodegradation in the toxicity control of a biodegradation study according to OECD 301 B with activated sludge from a sewage treatment plant. Therefore, inhibition of the degradation process in sewage treatment plants is not expected.
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