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EC number: 907-578-1 | CAS number: -
Table 1. Individual eye irritation scores
Time after dosing (h)
Fluor area (%)2
C – Remnants of the test item on the outside of the eyelids
Table 2. Animal specification
Age at start (weeks)
Body weights (g)
Prior to application
The eye irritation of dilithium azelate was assessed in a GLP-compliant, in vivo eye irritation study following OECD guidelines 405 (WIL Research 2015). A single treatment of dilithium azelate was applied to the non-irrigated eye of three rabbits and observations made at 1, 24, 48 and 72 hours for effects on conjunctivae, iris and cornea and for reversibility of effects.
Instillation of the dilithium azelate resulted in irritation of the conjunctivae, which consisted of redness, chemosis and discharge. The irritation had completely resolved within 72 hours in all animals. Based on the results, dilithium azelate does not have to be classified for eye irritation according to GHS and Regulation EC No. 1272/2008.
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