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Physical & Chemical properties

Melting point / freezing point

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Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From March 28th, 2018 to April 4th, 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
no
Qualifier:
equivalent or similar to
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
method to determine freezing temperature
Key result
Melting / freezing pt.:
-8.6 °C

Table 1. Measurements of the test item freezing point

Sample No. 1

Sample No. 2

Time

[min]

Sample temperature [ºC]

Time

[min]

Sample temperature [ºC]

1

-0.5

1

-0.5

2

-0.8

2

-1.0

3

-1.2

3

-1.4

4

-1.5

4

-1.8

5

-1.8

5

-2.1

6

-2.0

6

-2.5

7

-2.2

7

-2.7

8

-2.3

8

-3.0

9

-2.5

9

-3.2

10

-2.7

10

-3.4

11

-2.9

11

-3.8

12

-3.2

12

-4.0

13

-3.4

13

-4.2

14

-3.6

14

-4.5

15

-3.9

15

-4.8

16

-4.2

16

-5.1

17

-4.4

17

-5.4

18

-4.6

18

-5.7

19

-4.9

19

-5.9

20

-5.2

20

-6.2

21

-5.4

21

-6.5

22

-5.7

22

-6.7

23

-5.9

23

-6.9

24

-6.1

24

-7.1

25

-6.3

25

-7.3

26

-6.6

26

-7.6

27

-6.8

27

-7.8

28

-7.0

28

-7.9

29

-7.3

29

-8.1

30

-7.6

30

-8.3

31

-7.8

31

-8.4

32

-7.9

32

-8.6

33

-3.8

33

-8.4

 

 

34

-3.6

Conclusions:
The freezing temperature of the test item was -8.3 ± 0.5ºC.
Executive summary:

Determination of the freezing point of the test item was carried out following OECD guideline 102 and EU method A1, under GLP conditions. The method of crystallization tube in freezing mixture solid CO2/acetone was used. The temperature of the sample was read with an accuracy of 0.1°C. Measurements were taken at different times until the test item achieved crystallization. Two repetitions were performed. The freezing point of the test item was determined to be -8.3 ± 0.5ºC.

Description of key information

Key study. Method according to OECD 102 / EU A.1, GLP study. The test item freezing point was determined to be -8.3 ± 0.5ºC .

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
-8.3 °C

Additional information

Determination of the freezing point of the test item was carried out following OECD guideline 102 and EU method A1, under GLP conditions. The method of crystallization tube in freezing mixture solid CO2/acetone was used. The temperature of the sample was read with an accuracy of 0.1°C. Measurements were taken at different times until the test item achieved crystallization. Two repetitions were performed. The freezing point of the test item was determined to be -8.3 ± 0.5ºC.