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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Remarks:
Intravenous
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2000

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
No guideline is specified in the report.
GLP compliance:
no
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
3-[(4-aminobenzoyl)amino]propanoic acid
EC Number:
616-017-7
Cas Number:
7377-08-4
Molecular formula:
C10 H12 N2 O3
IUPAC Name:
3-[(4-aminobenzoyl)amino]propanoic acid

Test animals

Species:
rat
Strain:
other: Crl:CD (SD) BR
Sex:
male/female

Administration / exposure

Route of administration:
intravenous
Vehicle:
other: 1 N HCl (pH was adjusted to 4)
Details on exposure:
MAXIMUM DOSE VOLUME APPLIED: 5 mL/kg
Doses:
150 mg/kg bw
No. of animals per sex per dose:
3 animals per sex per dose
Control animals:
not specified
Details on study design:
All animals were observed for clinical signs and mortality for 48 hours. At the end of the observation period, all animals were sacrificed and subjected to complete necropsy.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 150 mg/kg bw
Remarks on result:
not determinable due to absence of adverse toxic effects
Mortality:
No mortality was observed during the test.
Clinical signs:
No clinical signs were observed during the test.

Applicant's summary and conclusion

Conclusions:
The acute intravenous non-lethal dose in rats was greater than 150 mg/kg.

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