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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
11 July - 18 July 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions) - Method B: Fibre Length and Diameter Distributions
Deviations:
no
Qualifier:
according to guideline
Guideline:
other: CIPAC MT 187
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
Laser scattering/diffraction
Type of particle tested:
primary particle
Type of distribution:
volumetric distribution
Specific details on test material used for the study:
- Test material: 4-Aminobenzoyl-b-alanine
- Batch number: 12/18
- Expiry date: 01 September 2019
- Storage: Room temperature
Key result
Percentile:
D10
Mean:
40 µm
St. dev.:
0
Remarks on result:
other: Standard deviations were not provided in the report
Key result
Percentile:
D50
Mean:
258 µm
St. dev.:
0
Remarks on result:
other: Standard deviations were not provided in the report
Key result
Percentile:
D90
Mean:
956 µm
St. dev.:
0
Remarks on result:
other: Standard deviations were not provided in the report
No.:
#1
Size:
< 45 µm
Distribution:
11.52 %
No.:
#2
Size:
> 75 µm
Distribution:
80.35 %

Table 1: Particle size distribution by laser diffraction

Test No.

Dv10 (µm)

Dv50 (µm)

Dv90 (µm)

% volume under 45 µm

% volume above 75 µm

1

39.7

256

995

11.64

80.17

2

40.1

258

927

11.51

80.32

3

40.3

261

946

11.42

80.55

Average

40.0

258

956

11.52

80.35

 

Conclusions:
The particle size distribution of 4-Aminobenzoyl-b-alanine is:
- Dv10: 40.0 µm
- Dv50: 258 µm
- Dv90: 956 µm
- <45 µm: 11.52%
- >75 µm: 80.35%

Description of key information

The particle size distribution of the test item, 4 -Aminobenzoyl-b-alanine was determined according to OECD Guideline 110 and CIPAC Method MT 187. It can be concluded that the 4 -Aminobenzoyl-b-alanine sample presents the following particle size distribution:

- Dv10: 40.0 µm

- Dv50: 258 µm

- Dv90: 956 µm

- <45 µm: 11.52%

- >75 µm: 80.35%

Additional information