4-Butoxy-2,3-difluor-4'-methyl-1,1'-biphenyl

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

February 07, 2013 - February 17, 2014

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Reason / purpose for cross-reference:

reference to other study

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

Version / remarks:

Range finding study of OECD Guideline 211

GLP compliance:

no

Analytical monitoring:

no

Test organisms (species):

Daphnia magna

Test type:

static

Water media type:

freshwater

Limit test:

yes

Total exposure duration:

48 h

Nominal and measured concentrations:

100 mg/L (nominal)

Key result

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Validity criteria fulfilled:

not applicable

Conclusions:

A non GLP preliminary range finding test was carried out as acute immobilisation test to Daphnia magna STRAUS. No immobilisation was observed after 24 h and 48 h at a nominal loading rate of 100 mg/L. The 48-h EC50 was determined to be greater than 100 mg/L.

Reference 2

Endpoint:

short-term toxicity to aquatic invertebrates

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because a long-term aquatic toxicity study on invertebrates is proposed to be conducted

Description of key information

According to Annex VII of REACH Regulation, the study does not need to be conducted because a long-term study on Daphnia magna is available.

However, a non GLP preliminary range finding test is available as acute immobilisation test to Daphnia magna STRAUS. No immobilisation was observed after 24 h and 48 h at a nominal loading rate of 100 mg/L. The 48-h EC50 was determined to be greater than 100 mg/L (nominal).