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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2017-03-28
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)
Deviations:
no
GLP compliance:
no
Type of method:
Laser scattering/diffraction
Type of particle tested:
agglomerate
Type of distribution:
volumetric distribution
Key result
Percentile:
D10
Mean:
19 µm
St. dev.:
1.13
Key result
Percentile:
D50
Mean:
100.7 µm
St. dev.:
5.3
Key result
Percentile:
D90
Mean:
278.8 µm
St. dev.:
7.21

The test item consisted of crystalline particles which built up bigger agglomerates. The test item was sieved with a mesh size of 1000 µm. 93.7 % (w/w) of the test item passed the sieve and only this fraction was measured with laser diffraction. After sieving, the particles soon started agglomerating again. The particles were introduced to the analyser beam by the dry powder feeder by direct spraying through the measurement area. The powder was loosened by an integrated vibrator. The particles were dispersed and fed to the optical system by pressurized dry air (1.5 bar). After passing the analyser beam the sample was collected in a vacuum cleaner. Two test series of three measurements each were performed. The measurement time was 8s.

 

The test item was sieved with a mesh size of 1000 µm. 93.7 % (w/w) of the test item passed the sieve and only this fraction was measured with laser diffraction.

 

The median particle size D50 of the test item deduced from the particle size distributions was 100.7 µm. The particle size D10 of the test item deduced from the particle size distributions was 19.0 µm. The particle size D90 of the test item deduced from the particle size distributions was 278.8 µm.

Conclusions:
The median particle size D10, D50 and D90 were determined to be 19.0 µm, 100.7 µm and 278.8 µm using laser diffraction.
Executive summary:

A study was conducted according to OECD TG 110, OPPTS 830.7520 and ISO 13320 in order to determine the particle size distribution of the test item (reference 4.5 -1). The particle size distribution was determined using laser diffraction. Two test series of three measurements each were performed. The measurement time was 8 s. The test item was sieved with a mesh size of 1000 µm. 93.7 % (w/w) of the test item passed the sieve and only this fraction was measured with laser diffraction. The median particle size D10, D50 and D90 were determined to be 19.0 µm, 100.7 µm and 278.8 µm respectively.

Description of key information

The median particle size D10, D50 and D90 were determined to be 19.0 µm, 100.7 µm and 278.8 µm using laser diffraction.

Additional information

A study was conducted according to OECD TG 110, OPPTS 830.7520 and ISO 13320 in order to determine the particle size distribution of the test item (reference 4.5 -1). The particle size distribution was determined using laser diffraction. Two test series of three measurements each were performed. The measurement time was 8 s. The test item was sieved with a mesh size of 1000 µm. 93.7 % (w/w) of the test item passed the sieve and only this fraction was measured with laser diffraction. The median particle size D10, D50 and D90 were determined to be 19.0 µm, 100.7 µm and 278.8 µm respectively.