Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 246-186-9 | CAS number: 24347-58-8
This in vitro study was performed to assess the irritation potential of 2,3-butanediol ((2R,3R)-rich) by means of the Human Skin Model Test according to OECD 439 (adopted 2015). Each three tissues of the human skin model EpiDerm™ were treated with the test item, the negative control (DPBS) or the positive control (5% SDS). The viability was measured after 60 min exposure and 42 hours post-incubation.
After treatment with the test item 2,3-butanediol ((2R,3R)-rich) the mean relative viability value decreased to 91.72% compared to the relative absorbance value of the negative control. This value is above the threshold for irritancy of≤50%. Therefore, the test item is not considered to possess an irritant potential. This study results were considered acceptable, because the treatment with the positive control induced a sufficient decrease in the relative absorbance as compared to the negative control for the 60 minutes treatment interval. The study was considered reliable and adequate as part of the hazard assessment of skin irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again