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EC number: 246-186-9 | CAS number: 24347-58-8
(OECD principle 3 - Applicability domain)
- Aquatic ECETOC
- Aquatic OASIS
- ECHA CHEM
Category boundaries (applicability domain):
- Active descriptor(s) range: - log Kow: from -1.2 to 4.77: target chemical is in domain
- Response range: EC50 <OR> LC50: from 1.01 to 4.37E+04 mg/L
- Basesurface narcotics (Acute aquatic toxicity MOA by OASIS) (primary grouping): target chemical is in domain
- Substance type (subcategorization): target chemical is in domain
- Aquatic toxicity classification by ECOSAR (subcategorization): target chemical is in domain
- Organic functional groups (US EPA) (subcategorization): target chemical is in domain
- Organic functional groups (subcategorization): target chemical is in domain
Additional data pruning:
- Data inconsistency filter 61 value(s) from 42 chemical(s)
- Filter by water solubility 98 value(s) from 53 chemical(s)
Manually eliminated data points:
Uncertainty of the prediction
(OECD principle 4 - Uncertainty of the prediction):
The prediction is based on 20 values within range 1,01 - 4,37E+04 mg/L
Prediction confidence range (0,95%): ± 0,857 log(1/mol/L)
(OECD principle 5 - Chemical and biological mechanisms)
log Kow (calculated): -0.36
For more details please refer to the prediction report.
In this study, fish toxicity of (2R,3R)-butane-2,3-diol was predicted using the OECD QSAR Toolbox 4.2 automated workflow (data gap filling method: Trend analysis, executed via Automated "Ecotoxicological Endpoint"). No adaptations such as data pruning were performed, and the automated prediction was accepted as valid by the programme.
The estimated lethal concentration (96h-LC50) was 2830 mg/L for Pimephales promelas. Therefore, (2R,3R)-butane-2,3-diol is not expected to pose an acute toxic hazard to fish. The prediction was considered reliable and adequate for the aquatic hazard assessment.
Estimated lethal concentrations: 96h-LC (Pimephales promelas) = 2830 mg/L (OECD QSAR Toolbox v4.2, Automated Workflow, 2018).
In a reliable key study fish toxicity of (2R,3R)-butane-2,3-diol was predicted using the OECD QSAR Toolbox 4.2 automated workflow (data gap filling method: trend analysis, executed via Automated "Ecotoxicological Endpoint"). No adaptations such as data pruning were performed and the prediction accepted as valid by the programme. The estimated lethal concentration 96h-LC50 was 2830 mg/L for Pimephales promelas. The prediction was considered reliable and adequate for aquatic hazard assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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