(2,5-dimethyl-2,3-dihydro-1H-inden-2-yl)methanol

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From January 26 to February 8, 2000

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

The study was conducted according to an internationally recognised method, and under GLP. No deviation affected the quality of the study. The substance is considered to be adequately characterised with its purity. Therefore full validation applies.

Reason / purpose for cross-reference:

reference to other study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

Principles of method if other than guideline:

Not applicable

GLP compliance:

yes (incl. QA statement)

Remarks:

inspected on September 22, 1999 / signed on January 18, 2000

Type of method:

flask method

Key result

Water solubility:

609 mg/L

Conc. based on:

test mat.

Loading of aqueous phase:

860 mg/L

Incubation duration:

24 - 72 h

Temp.:

20 °C

pH:

8.6 - 9.3

Details on results:

The solubility of the test material in water was found to be 609 ± 8 mg/L (RSD = 1%) at 20 ± 2 °C. The resulting saturated solutions were basic (pH 8.6 to 9.3) and whitish.

Preliminary test

This test was performed at 20 °C in vessels protected from light. The pH value of the water used was 9.15.

The preliminary test indicated that the test substance was soluble in water with solubility above 10 mg/L.

On the basis of these results, the final solubility determination was undertaken using the flask method

 

Flask method

The test was performed at 20 ± 2 °C, in vessels protected from light.

The solubility in water was found to be 609 ± 8 mg/L with a precision of 1%.

The water used had a pH value of 9.12. In the three replicate solutions prepared, the pH values were found to be 9.25, 8.88 and 8.59 (replicates 1 to 3).

 

Table 4.8/1: Water solubility of test item (Flask method)

 

Replicate number / Sampling Time	Water solubility (mg/L)
	First dilution	Second dilution	Mean (n=2)	Mean (n=6)
3 / T24h	606	596	601
2 / T48h	608	616	612
1 / T72h	613	617	615
				609
			SD	8
			RSD %	1

Conclusions:

Interpretation of results (migrated information): moderately soluble (100-1000 mg/L)

Executive summary:

The water solubility of the test substance was measured under GLP according OECD 105/EU A6 guideline, flask method.

Three measurements were performed at 48, 72 and 96 h, analysis were performed with HPLC-UV after suitable calibration, and dilution of the test samples. Equilibrium was achieved and the mean result was retained.

The water solubility of the test substance is 609 ± 8 mg/L (RSD = 1%) at 20 ± 2 °C. The resulting saturated solutions were basic (pH 8.6 to 9.3) and colourless.

Description of key information

Considered as moderately soluble, with equilibrium reached from 24h. pH of saturated solution: ca 9.

Key value for chemical safety assessment

Water solubility:

609 mg/L

at the temperature of:

20 °C

Additional information

A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. Therefore, it is considered as a key study, and the result is retained as key value.