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Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1969
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1970
Report date:
1969

Materials and methods

Principles of method if other than guideline:
yridamole, European J. Pharmacoi. 9 (1970) 265-268.
14C_labele d adenosine, inosine, adenine, hypoxanthine, uric acid or ribose were added at a dose of 0.004 umoles
to the perfusion fluid of isolated guinea-pig hearts. During a single passage through the heart, 30% of adenosine and
18% of inosine, but only 7% of adenine, 4.5% of hypoxanthine, 2% of uric acid and 2% of ribose was taken up.
Dipyridamole in a concentration of 10 -s M reduced the uptake of adenosine and inosine by 50%, but the uptake of
adenine, hypoxanthine, uric acid and ribose was not affected by dipyridamole, even with concentrations of 10 -s M.
Furthermore, the uptake of adenosine was inh~ited by inosine, but not by adenine or by hypoxanthine.
The octanol/water distribution of the compounds was studied to detect any influence of the degree of lipophilia
of each substance on its uptake by the heart. Of the following pairs of purine derivatives, adenosine : inosine and
adenine : hypoxanthine, the compound better taken up by the heart was also the more lipophilic of each pair.
However, the presence of ribose in the chemical structure appears to be of greater importance quantitatively in
determining the myocardial uptake of the purine derivatives.
GLP compliance:
no
Type of method:
estimation method (solubility ratio)
Partition coefficient type:
octanol-water

Test material

Constituent 1
Chemical structure
Reference substance name:
D-ribose
EC Number:
200-059-4
EC Name:
D-ribose
Cas Number:
50-69-1
Molecular formula:
C5H10O5
IUPAC Name:
D-ribose
Test material form:
solid: particulate/powder
Details on test material:
Dry powder, white to slightly yellow

Study design

Analytical method:
other: 14C count

Results and discussion

Partition coefficient
Key result
Type:
log Pow
Partition coefficient:
ca. -2.32
Temp.:
20 °C
pH:
ca. 7.4

Applicant's summary and conclusion

Conclusions:
Log Kow of D-Ribose at pH 7.4 is -2.32