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Environmental fate & pathways

Adsorption / desorption

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Reference
Endpoint:
adsorption / desorption: screening
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Oct 22, 2020
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
Version / remarks:
22 January, 2001
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC estimation method
Media:
soil
Radiolabelling:
no
Test temperature:
30 ℃
Details on study design: HPLC method:
EQUIPMENT
- Apparatus: HPLC e2695-2489 (C2019-002), XS205 electronic balance (P-228)
- Column:ECLIPSE XDB-CN (4.6×250 mm, 5μm)
- Oven temperature: 30℃
- Detector: UV
- Detection wavelength: 254 nm

MOBILE PHASES
- Type: Methanol/Water = 60/40 (v/v)
- Flow rate:1.2 mL/min
- Injection volume:10.0 µL

DETERMINATION OF DEAD TIME
- Method: NaNO3 was employed to determine the dead time t0.

REFERENCE SUBSTANCES
- Identity: Six reference points, including phenol, atrazine, carbendazim, naphthalene, triazophos and phenanthrene, were used.

REPETITIONS
- Number of determinations: 2

EVALUATION
- Calculation of capacity factors k': k'=(tR-t0)/t0
- Calculation of retention times:
- Determination of the log Koc value: logKoc = a*logk'+b
Key result
Type:
log Koc
Value:
1.59
Temp.:
30 °C
Details on results (HPLC method):
In the first injection sequence, the retention time of the test item was 2.889 min, which was in the range of the retention times of the six reference substances. The calibration curve was LogKoc=4.5063×logk'+1.9833, and the calculated LogKoc value of the test item was 1.57.
In the second injection sequence, the retention time of the test item was 2.887 min, and the calibration curve was LogKoc=4.4176×logk'+2.0073, the calculated LogKoc value of the test item was 1.60.
The average LogKoc of the test item in the two injection sequences was 1.59, and the deviation was -0.03.
Validity criteria fulfilled:
yes
Conclusions:
The estimated logKoc value of the test item was 1.59.
Executive summary:

This test was performed according to the OECD121: Estimation of the Adsorption Coefficient(Koc) on soil and Sewage Sludge using High Performance Liquid Chromatography (HPLC), to estimate the logKoc of the test item.


The average LogKoc of the test item in the two injection sequences was 1.59, and the deviation was -0.03.

Description of key information

This test was performed according to the OECD121: Estimation of the Adsorption Coefficient(Koc) on soil and Sewage Sludge using High Performance Liquid Chromatography (HPLC), to estimate the logKoc of the test item.


The average LogKoc of the test item in the two injection sequences was 1.59, and the deviation was -0.03.

Key value for chemical safety assessment

Additional information