Registration Dossier
Registration Dossier
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EC number: 289-227-6 | CAS number: 86362-36-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Final Report on the Safety Assessment of Tocopherol, TocopherylAcetate, TocopherylLinoleate, TocopherylLinoleate/Oleate, TocopherylNicotinate, TocopherylSuccinate, DioleylTocopherylMethylsilanol, Potassium Ascorbyl Tocopheryl Phosphate, Tocophersolan
- Author:
- Monice Zondlo Fiume
- Year:
- 2 002
- Bibliographic source:
- International Journal of Toxicology, 21 (Suppl. 3): 51-116, 2002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- α-tocopherol
- EC Number:
- 200-412-2
- EC Name:
- α-tocopherol
- Cas Number:
- 59-02-9
- Molecular formula:
- C29H50O2
- IUPAC Name:
- (2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-ol
- Test material form:
- liquid: viscous
Constituent 1
Test animals
- Species:
- rat
- Details on test animals or test system and environmental conditions:
- Details not provided.
Administration / exposure
- Route of administration:
- oral: unspecified
- Details on oral exposure:
- Details not provided.
- Doses:
- 4000 mg/kg bw
- Details on study design:
- Details not provided.
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 4 000 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The oral LD50 of Tocopherol was stated as > 4 g/kg for rats.
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