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EC number: 428-650-4 | CAS number: 153719-23-4
In an acute inhalation toxicity study, groups of young adult SPF Sprague-Dawley (Crj:CD) rats (10 male and 10 female) were exposed by inhalation route to pulverized test substance (purity: 98.60%) in the form of a dust for 4 hours (in a nose only exposure chamber) at concentrations of 1.02 (group 1) and 3.72 mg/L (group 2). Animals then were observed for 14 days. Two groups of five male and five female SPF Sprague-Dawley were exposed nose-only for a four-hour period to the test substance at a target formulation concentration of 5 mg/L. Test atmospheres were analysed for particulate concentration. The particle size distribution of the test atmosphere was analysed twice during the exposure period. Following exposure, the animals were retained without treatment for 14 days. Clinical observations and body weights were recorded throughout the study and at the end of the scheduled period, the animals were killed and subjected to a gross examination post mortem. The achieved test atmosphere had the following characteristics: Target concentration (mg/L) = 5; achieved particulate concentration (mg/L) = 3.72 ± 0.73; MMAD (µm) = 5.1, 5.6; GSD = 2.1, 1.8.There were no deaths in either sexes throughout the observation in both groups. The median lethal concentration of the test substance for male and female rats was more than 3.72 mg/L. No abnormalities were found in the major organs in the cranial, thoracic, and abdominal cavities in any animal of either group at necropsy. From these results, it was concluded that the acute inhalation toxicity of the test substance in Sprague-Dawley rats was virtually nontoxic at the atmospheric concentration of 3.72 mg/L and the LC50 for male and female rats was more than 3.72 mg/L.
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