Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 428-650-4
CAS number: 153719-23-4
an acute inhalation toxicity study, groups of young adult SPF
Sprague-Dawley (Crj:CD) rats (10 male and 10 female) were exposed by
inhalation route to pulverized test substance (purity: 98.60%) in the
form of a dust for 4 hours (in a nose only exposure chamber) at
concentrations of 1.02 (group 1) and 3.72 mg/L (group 2). Animals then
were observed for 14 days. Two groups of five male and five female SPF
Sprague-Dawley were exposed nose-only for a four-hour period to the test
substance at a target formulation concentration of 5 mg/L. Test
atmospheres were analysed for particulate concentration. The particle
size distribution of the test atmosphere was analysed twice during the
exposure period. Following exposure, the animals were retained without
treatment for 14 days. Clinical observations and body weights were
recorded throughout the study and at the end of the scheduled period,
the animals were killed and subjected to a gross examination post
mortem. The achieved test atmosphere had the following characteristics: Target
concentration (mg/L) =
5; achieved particulate concentration (mg/L) = 3.72
MMAD (µm) = 5.1, 5.6; GSD = 2.1, 1.8.There
were no deaths in either sexes throughout the observation in both
groups. The median lethal concentration of the test substance for male
and female rats was more than 3.72 mg/L. No abnormalities were found in
the major organs in the cranial, thoracic, and abdominal cavities in any
animal of either group at necropsy. From these results, it was concluded
that the acute inhalation toxicity of the test substance in
Sprague-Dawley rats was virtually nontoxic at the atmospheric
concentration of 3.72 mg/L and the LC50 for male and female rats was
more than 3.72 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again