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EC number: 428-650-4 | CAS number: 153719-23-4
In an acute oral toxicity study, 6 groups of 7 week old Crj:CD (SD) strain rats (each group consisting of 5 animals of each sex), were given a single oral dose of the test substance (98.60%.) in methylcelluloseat doses of 900, 1500, 2300, 3800 or 6000 mg/kg bw and observed for 14 days. A control group consisting of 5 male and 5 female rats were treated with 0.5% methylcellulose solution alone and were also observed. The animals were examined frequently for the first six hours after dosing and twice daily in the morning and afternoon thereafter for 14 days for mortality and clinical abnormalities during the study. Body weights were recorded throughout the study. In the males and females in each group, ptosis was observed beginning from one hour after dosing. In each sex in the 1500mg/kg bw and above groups, decrease in spontaneous movement and tonic convulsion were also observed. Initial deaths were seen at the 1500 mg/kg bw group with 3 animals of each sex, this was also seen with 4 animals of each sex in the 2300 mg/kg bw group and all animals in the 3800 and 6000 mg/kg bw group. The oral LD50 for males and for females is 1563 mg/kg bw (95% CI 1086 – 2174 mg/kg bw). The combined (males and females) oral LD50 1563 mg/kg bw (95% CI 1267 – 1905 mg/kg).
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