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EC number: 428-650-4 | CAS number: 153719-23-4
Endocrine disrupting properties
Following evaluation of each of the relevant studies individually and a subsequent weight of evidence evaluation, it can be concluded that the test substance cannot be considered an endocrine disrupter as defined by WHO/IPCS (2002) (Charlton A, 2015).
A publication by Rotroff et al (2014) provides a novel method for combining in vitro concentration response data from multiple assays and, when applied to a large set of oestrogen receptor signalling data, accurately predicted estrogenic responses and demonstrated its utility for chemical prioritization challenges. The test substance exerted no response in any assay, indicating no evidence of a direct effect on the endocrine system.
One important mode of action leading to toxicity is endocrine disruption, and the U.S. EPA’s Endocrine Disruptor Screening Program (EDSP) has been charged with screening pesticide chemicals and environmental contaminants for their potential to affect the endocrine systems of humans and wildlife. The test substance is not highlighted as an EDSP chemical (Reif, 2010).
A publication of Yéboué-Kouamé et al. (2010) describes the case study of a 37 year old farmer who had been exposed to a pesticide containing 106 g lambda-cyhalothrin and 141 g test substance presented with lesions indicative of Stevens-Johnson syndrome. It is not possible to exclude a link between this case of Stevens-Johnson syndrome and insecticide exposure.
Testis toxicity in the dog and rat
The test substance shows no evidence of direct interaction with the endocrine system or indirect interaction with the endocrine system through disruption of the HPT axis (Charlton A, 2016).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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