Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Jan - Mar 2019
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Cross-reference
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2019

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient - Shake Flask Method)
Version / remarks:
2016
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Version / remarks:
1995
Qualifier:
according to
Guideline:
EPA OPPTS 830.7550 (Partition Coefficient, n-octanol / H2O, Shake Flask Method)
Version / remarks:
1996
GLP compliance:
yes
Type of method:
flask method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Details on test material:
- Identification: Zirconium (IV) acetylacetonate (Zr-acac)
- Description: White to off-white powder
- Storage conditions: At room temperature

Results and discussion

Partition coefficientopen allclose all
Key result
Type:
log Pow
Partition coefficient:
0.2
Temp.:
20 °C
pH:
7.1
Remarks on result:
other: based on acetylacetone analysis
Key result
Type:
Pow
Partition coefficient:
1.75
Temp.:
20 °C
pH:
7.1
Remarks on result:
other: based on acetylacetone analysis
Type:
log Pow
Partition coefficient:
< 0.12
Temp.:
20 °C
Remarks on result:
other: based on Zr-ion analysis
Type:
Pow
Partition coefficient:
< -0.93
Temp.:
20 °C
Remarks on result:
other: based on Zr-ion analysis
Details on results:
- Concentration analysed in the stock solution: nominal concentration of 1.58 g/L, based on acetylacetone analysis; nominal concentration of 2.00 g/L, based on Zr-ion analysis.
- Nominal quantity of the substance in each test sample: 3.16 mg (based on acetylacetone analysis); 4 mg (based on Zr-ion analysis).
- Recovery (range) for the test samples: 106% - 110% (based on acetylacetone analysis); 92% - 110% (based on Zr-ion analysis).
- The log Pow values were within the criterion range of ± 0.3 log units (see table below)

Applicant's summary and conclusion

Conclusions:
The log Pow of the substance at pH 7 and 20°C was determined to be 0.2 (based on acetylacetone analysis).