Registration Dossier

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

Administrative data

Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Study period:
December 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Data source

Reference
Reference Type:
other: QSAR prediction
Title:
PQSAR v1.1
Author:
ProtoQSAR
Year:
2018
Bibliographic source:
ProtoQSAR SL, CEEI Valencia, Parque Tecnológico de Valencia, Avda. Benjamin Franklin 12, Desp. 8, 46980 Paterna (Valencia), Tel. +34 960 88 06 58, E-mail. info@protoqsar.com

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 201 (Alga, Growth Inhibition Test)
Deviations:
no
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Specific details on test material used for the study:
SMILES: CCOC(=O)CC(=O)OCC(=O)OCC

Test organisms

Test organisms (species):
Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum)

Study design

Test type:
static
Water media type:
freshwater
Total exposure duration:
72 h

Results and discussion

Effect concentrations
Duration:
72 h
Dose descriptor:
EC50
Effect conc.:
151.35 mg/L
Nominal / measured:
estimated
Basis for effect:
growth rate
Remarks on result:
other: QSAR prediction

Any other information on results incl. tables

The estimated value for 2-ethoxy-2-oxoethyl ethyl malonate after applying the ProtoQSAR model for acute aquatic toxicity in algae was 151.35 mg/L. The prediction, falls inside the applicability domain of the model and is considered reliable.

Applicant's summary and conclusion

Conclusions:
PQSAR model for acute aquatic toxicity in algae estimated for 2-ethoxy-2-oxoethyl ethyl malonate an acute 72h EC50 to algae of 151.35 mg/L. The prediction, falls inside the applicability domain of the model and is considered reliable. Furthermore, and based on the Globally Harmonized System of Classification and Labelling (CLP/GHS) , the test compound is considerd non-toxic / non-harmful. 151.35 mg/L > 100.
Executive summary:

Regulatory purpose: This study was designed to generate estimated in silico (nontesting) data for acute aquatic toxicity in algae for 2-ethoxy-2-oxoethyl ethyl malonate to be used in the regulatory framework of REACH. EC50 = 151.35 mg/L

On the basis of EC 50 value it is concluded that this test chemical is considered to be not classified according to CLP classification criteria.