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Long-term toxicity to fish

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Description of key information

No data on chronic toxicity to fish is available for HiMO LAB.  Data from LAB (CAS no: 67774-74-7) as structural analogue  was used to understand the chronic toxicity profile of substance to fish. The 14-day NOEC value for LAB  was > 10 ug/L.  As a consequence, due to the extremely low water solubility,  the chronic toxicity is above the water solubility (<0.1 mg/L).

Key value for chemical safety assessment

Additional information

Benzene, C16-24 alkyl derivatives are also known as High Molecular Weight Linear Alkylbenzenes (HiMo LAB).  The substance is a UVCB. Because of their high molecular weight, they are very similar in composition and properties to the heavy alkylate bottoms (HAB). Based on these structural and functional similarities, data on LAB (CAS no: 67774-74-7) being registered under REACH, LAB Alkylate Bottoms (CAS no: 85117-41-5) described in OECD SIDS dossier, and HAB (CAS no: 84961-70-6) being registered under REACH are suitable as supporting studies in case where specific data on the HiMo LAB is lacking. 

There is no chronic fish study available with HiMo LAB. The study from Benzene, C10-13-alkyl derivs. (LAB, CAS No 67774-74-7) as structural analogue was used to cover this endpoint.

The toxicity of LAB to fish was determined in an extended acute study according to OECD 204 as indicated in 6.1.1. No adverse effects were observed for the concentrations tested during the study period. A decrease in the test substance concentration was observed within 24 hours (day 1 and day 14), but the daily renewal of test solutions maintained the exposure to the test substance. Both the LOEC and NOEC were higher than the solubility concentration of >10 ug/L/day.

The EPISUITE QSAR modelling was used to predict the chronic toxicity profile of HiMo LAB. Modelled toxicity values for HiMo LAB (C20 and C24 alkyl derv.) confirmed that the aquatic chronic toxicity value exceeds (i) the predicted water solubility, indicating the substance is not soluble enough to measure the predicted effect and (ii) the log Kow cutoff value of 8.0 for chronic toxicity to fish

 

According to data from analogue substances and QSAR modelling of HiMo LAB, the substance does not demonstrate chronic aquatic toxicity at water soluble concentrations.

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