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Physical & Chemical properties

Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1988-09-07 to 1988-11-14
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
1981
Deviations:
no
GLP compliance:
not specified
Type of method:
gas saturation method
Key result
Temp.:
27 °C
Vapour pressure:
< 0 Pa

Results and discussion:

The minimum quantifiable amount of D-8 was 0.5 ng, i.e. 210 of the integral peak area at AUFS. Taking account into interferences, the detection limit was set at 1 ng / 20 μL injection. This concentration makes the total quantity (W) of 25 ng in 0.5 mL of the final solution. If we use W = 25 x 10-9 g, V = 87.2 L (20.0 mL/min x 4360 min), T = 300 and M = 292.4, a minimum measurable limit of the vapour pressure is calculated as 2.4E-6 Pa.

The experimental results are summarized in Table 1. Each value is mean of duplicate measurements in HPLC for the same sample.

 

Table 1: Vapor Pressure of D-8.

Exp.

N2

Absorbed D-8 (x10-9 g)

Vapor pressure

No.

passing time (min)

total volume (L)

(x10-8 mmHg)

x10-6 Pa)

1

4065

81.3

98*

7.7

10.3

2

4360

87.2

49

3.6

4.8

3

2600

52.0

32

3.9

5.2

4

4360

87.2

50

3.7

4.9

Av. ± 2σ

-

-

-

4.7 ± 4.0

6.3 ± 5.3

 

Conclusions:
The vapour pressure of D-8 was measured by a gas saturation method as described in the OECD Guideline 104. The vapour pressure of D-8 was less than 1.0E-05 Pa at 27 °C.
Executive summary:

The vapour pressure of D-8 was measured using a gas saturation method as described in the OECD guideline 104. In this procedure, a stream of inert carrier gas is passed over the substance in such a way that it becomes saturated with its vapour. The amount of material transported by a known amount of carrier gas is measurable either by collection in a suitable trap or by an intrain analytical technique. This was then used to calculate the vapour pressure at a given temperature. According to this test method, the vapour pressure of D-8 was less than 1.0E-05 Pa at 27 °C.

Description of key information

The vapour pressure of D-8 was measured by a gas saturation method as described in the OECD Guideline 104. The vapour pressure of D-8 was less than 1.0E-05 Pa at 27 °C.

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
27 °C

Additional information

The vapour pressure of D-8 was measured using a gas saturation method as described in the OECD guideline 104. In this procedure, a stream of inert carrier gas is passed over the substance in such a way that it becomes saturated with its vapour. The amount of material transported by a known amount of carrier gas is measurable either by collection in a suitable trap or by an intrain analytical technique. This was then used to calculate the vapour pressure at a given temperature. According to this test method, the vapour pressure of D-8 was less than 1.0E-05 Pa at 27 °C.