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Registration Dossier
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Diss Factsheets
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EC number: 700-697-8 | CAS number: 264145-26-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 to 18 April 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study undertaken at a GLP accredited laboratory, to internationally accepted guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 439 (Reconstructed Human Epidermis Test Method)
- Deviations:
- yes
- Remarks:
- The description of the colour of the test substnce was amended to light yellowish green powder as required by the Sponsor. The change in description of the test material is not considered to affect the scientific integrity of the study.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- LumiNova Blue Green
- IUPAC Name:
- LumiNova Blue Green
- Details on test material:
- - Name of test material (as cited in study report): LumiNova Blue Green
- Substance type: Phosphorescent pigment
- Physical state: Light yellowish green powder
- Analytical purity: > 99%
- Lot/batch No.: PBM-029
- Expiration date of the lot/batch: 04 February 2012
- Storage condition of test material: Room temperature in the dark
Constituent 1
Test animals
- Species:
- other: None
- Strain:
- other: None
- Details on test animals or test system and environmental conditions:
- Not applicable
Test system
- Type of coverage:
- other: Not applicable
- Preparation of test site:
- other: Not applicable
- Vehicle:
- other: Not applicable
- Controls:
- other: No control animals were used but control substances were employed.
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 10 ± 2 mg
VEHICLE
- Amount applied: none - Duration of treatment / exposure:
- 15 ± 0.5 minutes
- Observation period:
- 42 hours
- Number of animals:
- None; in vitro study
- Details on study design:
- TEST SITE
- Area of exposure: 0.38 cm2
REMOVAL OF TEST SUBSTANCE
- Washing (if done): each tissue was rinsed with 25 ml sterile Dulbeccos Phosphate Buffered Saline (DPBS) to remove residual test substance.
- Time after start of exposure: 15 ± 0.5 minutes
CONTROLS
The negative control was sterile Dulbecco’s Phosphate Buffered Saline (DPBS) with magnesium and calcium.
The positive control was 5% (w/v) Sodium Dodecyl Sulphate (SDS) in distilled water.
SCORING SYSTEM: If the mean tissue viability was equal to or less than 50% of the negative control value, the sample was classed as Irritant R38 (EU classification) or Category 2 (GHS classification).
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- other: other: Optical density
- Value:
- 99.5
- Remarks on result:
- other:
- Remarks:
- Basis: mean. Time point: 45 hours. Max. score: 100.9. Reversibility: no data. (migrated information)
Any other information on results incl. tables
EPISKIN results - Tissue viability as percentage of mean OD negative control
Sample | Replicate tissues | Mean ± SD | Prediction MTT endpoint | ||
a | b | c | |||
Negative control | 92.1 | 97.3 | 110.5 | 100 ± 9.5 | Not applicable |
Positive control |
38.7 | 29.6 | 26.9 | 31.8 ± 6.2 | Irritant |
LumiNova Blue Green |
100.9 | 100.5 | 96.9 | 99.5 ± 2.2 | Non-irritant |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- It was concluded that the test substance, LumiNova Blue Green, with a mean tissue viability of 99.5 ± 2.2%, was predicted as a non - irritant to the skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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