Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented study using standard protocols.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPP 81-4 (Acute Eye Irritation)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- tris isodecyl phosphite
- IUPAC Name:
- tris isodecyl phosphite
- Test material form:
- other: liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: right eye served as control for each rabbit
- Amount / concentration applied:
- 0.1 gram applied in left eye of each rabbit
- Duration of treatment / exposure:
- 4 days
- Observation period (in vivo):
- 4 days
- Number of animals or in vitro replicates:
- 6 rabbits
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 1-4 days
- Remarks on result:
- other: no responses
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 1-4 days
- Remarks on result:
- other: no responses
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 1-4 days
- Remarks on result:
- other: no responses
- Irritant / corrosive response data:
- No responses/effects observed in any of the rabbits.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- No irritation effects observed. The substance is not irritating to eyes.
- Executive summary:
No irritation effects observed. The substance is not irritating to eyes.
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