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EC number: 265-409-0 | CAS number: 65104-06-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1st February - 23rd February, 2019
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- Identification Tyzor LA
Appearance A Clear to slightly hazy, colorless to light yellow liquid
Manufacturer’s address Dorf Ketal Chemicals India Private Limited,Plot no. 2, Block – F, Sector – 12N,Adani Ports & SEZ, Taluka – Mundra,District – Kutch, Gujarat – 370421.
Chemical Name Diammonium dihydroxybis[lactato(2-)-01, 02]titanate(2-)
Batch No. 334-300149/000160
CAS No. 65104-06-5
Formulation type Chemical
Molecular weight 298.1484
Molecular Formula C6H22N2O8Ti
Purity 99 %
Manufacturing date April, 2018
Expiry date March, 2020
Stability The product is stable under storage at normal ambient temperature
Storage conditions Room Temperature (20 to 30ºC) - Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- >= -1.38 - <= 0
- Temp.:
- 25 °C
- pH:
- 7
- Conclusions:
- The log Pow value shall be approximated to -1.38 and < 0 from HPLC method of partition coefficient determination.
- Executive summary:
The present study was conducted to determine the Partition Coefficient [n-Octanol / water (Pow)]forthe solid test item “Tyzor LA” by shake flask method / HPLC method in accordance with current OECD testing guidelines.
The HPLC method did not suite for validation since the test item did not pass through minimum theoretical plates to achieve good separation and constant retention time. Hence UV-Visible spectrometric method was developed and validated for quantization of test item in water saturated n-octanol and n-octanol saturated water.
During the assay accuracy phase of method validation, the UV-Vis absorbance spectrum revealed a different pattern for n-octanol saturated water and water saturated n-octanol. However with pure water and octanol, the data generated was reliable and was on par with theoretical values. Hence based on solubility data at the level of 0.01M concentration the approximate log Pow value was -1.38.
To substantiate the partitioning of the test item towards aqueous medium it has been decided to go with OECD 117 guidelines, HPLC method of partition coefficient determination. The result from this method clearly depicted that the test item partitioning was more towards aqua layer than n-octanol layer. But the result on the retention time clearly augment that the log Pow value was less than zero but without any concrete value. The reason is extrapolation cannot be carried out for any value on retention time lesser than Thiourea, (log Pow = 0).
Based on the facts Viz., higher solubility of test item in water, poor solubility in n-octanol, test item different behavior in water saturated n-octanol and the lesser retention time than the dead retention time pertaining to thiourea, the actual value on Pow cannot be precisely and accurately defined. However with the above mentioned solubility of test item to a concentration level of 0.01M, the log Pow value shall be approximated to -1.38 and < 0 from HPLC method of partition coefficient determination.
Reference
Description of key information
Partition Coefficient (Tyzor LA; OECD 107): log Pow between -1.38 and 0
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -0.69
- at the temperature of:
- 25 °C
Additional information
The present study was conducted to determine the Partition Coefficient [n-Octanol / water (Pow)] for the solid test item “Tyzor LA” by shake flask method / HPLC method in accordance with current OECD testing guidelines.
The HPLC method did not suite for validation since the test item did not pass through minimum theoretical plates to achieve good separation and constant retention time. Hence UV-Visible spectrometric method was developed and validated for quantization of test item in water saturated n-octanol and n-octanol saturated water.
During the assay accuracy phase of method validation, the UV-Vis absorbance spectrum revealed a different pattern for n-octanol saturated water and water saturated n-octanol. However with pure water and octanol, the data generated was reliable and was on par with theoretical values. Hence based on solubility data at the level of 0.01M concentration the approximate log Pow value was -1.38.
To substantiate the partitioning of the test item towards aqueous medium it has been decided to go with OECD 117 guidelines, HPLC method of partition coefficient determination. The result from this method clearly depicted that the test item partitioning was more towards aqua layer than n-octanol layer. But the result on the retention time clearly augment that the log Pow value was less than zero but without any concrete value. The reason is extrapolation cannot be carried out for any value on retention time lesser than Thiourea, (log Pow = 0).
Based on the facts Viz., higher solubility of test item in water, poor solubility in n-octanol, test item different behavior in water saturated n-octanol and the lesser retention time than the dead retention time pertaining to thiourea, the actual value on Pow cannot be precisely and accurately defined. However with the above mentioned solubility of test item to a concentration level of 0.01M, the log Pow value shall be approximated to -1.38 and < 0 from HPLC method of partition coefficient determination.
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