Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 258-847-9 | CAS number: 53894-23-8
Endpoint summary
Administrative data
Description of key information
Additional information
Acute immobilisation in Daphnia has been investigated in a 48 hour test according to OECD test methods and using dissolution/dispersion agents to increase concentration of the substance in the test medium. The EC50 (48h) was determined to be >180 mg/L and the NOEC was 180 mg/L, the highest concentration investigated.
Algal growth inhibition has been investigated in a 72 hour test according to OECD test methods and using dissolution/dispersion agents to increase concentration of the substance in the test medium. The EC50 (72h) was determined to be >100 mg/L and the NOEC was 100 mg/L, the highest concentration examined.
Acute toxicity to fish has been investigated in a 96 hour test according to OECD test methods and using dissolution/dispersion agents to increase concentration of the substance in the test medium. The LC50 (96h) was determined to be >100 mg/L.
Chronic toxicity to Daphnia has been investigated in a 21 -day reproduction test 48 hour test according to OECD test methods and using dissolution/dispersion agents to increase concentration of the substance in the test medium. The NOEC (21 -day, reproduction) was 55.6 mg/L; LOEC (21 -day, reproduction) was >100 mg/L and the EC50 (21 -day, reproduction) was 89.1 mg/L. A second chronic Daphnia study has been conducted according to ASTM/EPA test methods, again using dissolution/dispersion agents to increase concentration of the substance in the test medium. The following values were calculated: NOEC (21 -day, reproduction): 0.082 mg/L; LOEC (21 -day, reproduction): >0.082 mg/L; EC50 (21 -day, reproduction): >0.082 mg/L. These lower values compared with the first study reflect the achieved concentrations of the substance in the test media, this influenced by the agents used to achieve dissolution/dispersion.
Toxicity to fish has been investigated in 14 day test according to OECD test methods using dissolution/dispersion agents to increase concentration of the substance in the test medium. The 14 day NOEC was determined to be 75.0 mg/L. It is recognised that the duration of the OECD TG 204 test is shorter than that currently accepted for investigating long-term toxicity in fish. Waiving of repeat or additional testing is proposed based both on the lack of effects seen in the 14 -day fish study and chronic Daphnia reproduction studies together with considerations regarding adequate justification for the use of vertebrate species for experimental purposes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
