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Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Reference
Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
Please refer to the attached analogue justification provided in IUCLID Section 13.
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Duration:
72 h
Dose descriptor:
EC50
Effect conc.:
> 5.3 mg/L
Nominal / measured:
meas. (geom. mean)
Conc. based on:
test mat.
Basis for effect:
growth rate
Remarks on result:
other: Source: CAS 68583-51-7
Duration:
72 h
Dose descriptor:
NOEC
Effect conc.:
>= 5.3 mg/L
Nominal / measured:
meas. (geom. mean)
Conc. based on:
test mat.
Basis for effect:
growth rate
Remarks on result:
other: Source: CAS 68583-51-7
Duration:
72 h
Dose descriptor:
EC50
Effect conc.:
> 3 mg/L
Nominal / measured:
meas. (initial)
Conc. based on:
test mat.
Basis for effect:
growth rate
Remarks on result:
other: Source: CAS 853947-59-8
Duration:
72 h
Dose descriptor:
NOEC
Effect conc.:
>= 3 mg/L
Nominal / measured:
meas. (initial)
Conc. based on:
test mat.
Basis for effect:
growth rate
Remarks on result:
other: Source: CAS 853947-59-8

Description of key information

No toxicity towards algae based on read across from CAS 68583-51-7 and CAS 853947-59-8

Key value for chemical safety assessment

Additional information

No experimental data are available, testing the toxicity of propylene dinonanoate (CAS 41395-83-9) towards algae. Therefore, read-across to the structurally related source substances decanoic acid, mixed diesters with octanoic acid and propylene glycol (CAS 68583-51-7) and butylene glycol dicaprylate / dicaprate (CAS 853947-59-8) was performed in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5. The source substances are characterized by similar fatty acid chain lengths as well as alcohol components and are therefore considered suitable representatives for the assessment of the toxicity of the target substance to algae. A detailed read-across justification is provided in the analogue justification in IUCLID section 13.

All available studies with the source substances were performed according to appropriate EU guidelines and GLP.

One experimental study investigating the toxicity of the source substance decanoic acid, mixed diesters with octanoic acid and propylene glycol (CAS 68583-51-7) to aquatic algae is available (1995). The study was performed according to the EU Method C.3 under GLP conditions. The green algae Scenedesmus subspicatus was exposed to a Water Accommodated Fraction (WAF) of nominal 5.3 mg/L and subsequent dilutions for 72 h. No effects on the growth rate of S. subspicatus up to the limit of water solubility were observed resulting in an ErL50 (72 h) > 5.3 mg/L and a NOELR (72 h) of ≥ 5.3 mg/L (nominal, WAF).

Further experimental data are available for the source substance butylene glycol dicaprylate / dicaprate (CAS 853947-59-8). The available study was conducted according to the EU Method C.3 and GLP (1997). Desmodesmus subspicatus was exposed for 72 h to a single test item loading rate of 1000 mg/L (WAF) and a control. The substance was analytically monitored by TOC measurements. The concentration of the stock solution was 3.3 mg/L (0 h) based on the TOC content. The recovery rate in the stability test was > 80% and the concentration after 48 and 72 h did not differ > 20%. Therefore, the test substance was bioavailable throughout the test. The test showed no toxicity effects resulting into an ErC50 (72 h) > 3 mg/L and a NOEC (72 h) ≥ 3 mg/L (meas. initial).

Based on the results from the structurally related read-across substances, it can be concluded that propylene dinonanoate (CAS 41395-83-9) will not cause acute or chronic effects to algae up to the limit of the water solubility.