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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
Please refer to the attached analogue justification provided in IUCLID Section 13.
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
> 2.4 mg/L
Nominal / measured:
meas. (geom. mean)
Conc. based on:
test mat.
Basis for effect:
mobility
Remarks on result:
other: Source: CAS 68583-51-7
Duration:
48 h
Dose descriptor:
EL50
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Remarks:
WAF
Basis for effect:
mobility
Remarks on result:
other: Source: CAS 853947-59-8

Description of key information

No short term toxicity towards aquatic invertebrates based on read across from CAS 68583-51-7 and CAS 853947-59-8

Key value for chemical safety assessment

Additional information

There is no study available, in which the short-term toxicity of propylene dinonanoate (CAS 41395-83-9) to aquatic invertebrates was investigated. Therefore, read-across to the structurally related source decanoic acid, mixed diesters with octanoic acid and propylene glycol (CAS 68583-51-7) and butylene glycol dicaprylate / dicaprate (CAS 853947-59-8) was performed in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5. The source substances are characterized by similar fatty acid chain lengths as well as alcohol components and are therefore considered suitable representatives for the assessment of the short-term toxicity of the target substance to aquatic invertebrates. A detailed read-across justification is provided in the analogue justification in IUCLID section 13.

All available studies with the source substances were performed according to appropriate EU guidelines and GLP.

One experimental study investigating the short-term toxicity of the source substance decanoic acid, mixed diesters with octanoic acid and propylene glycol (CAS 68583-51-7) to aquatic invertebrates is available (1995). It was performed according to EU Method C.2 (GLP) with Daphnia magna in a static exposure regime. The test species were exposed to a Water Accommodated Fraction (WAF) of 1000 mg/L (nominal) for 48 h. A DOC analysis of the WAF resulted in a test substance concentration of 2.4 mg/L (meas. geom. mean). Since no effects were observed after 48 h an EC50 of > 2.4 mg/L (meas. geom. mean) was derived.

A further study is available testing the short-term toxicity of the source substance butylene glycol dicaprylate / dicaprate (CAS 853947-59-8) to aquatic invertebrates according to EU Method C.2 and GLP (1997). Daphnia magna as the test organism was exposed in a limit test to 1000 mg test item/L (WAF) and a control for 48 h. The concentration of the stock solution was measured via TOC and was 2.2 mg/L (0 h). The recovery rate in the stability test was > 80% and the concentration after 48 and 72 h did not differ more than 20%. Therefore, the test substance was bioavailable throughout the test. No toxicity effects were recorded resulting in an EL50 (48 h) > 1000 mg/L (nominal, WAF).

All data with the source substances consistently showed no toxicity effects towards aquatic invertebrates up to the water solubility limit. Based on the structural and chemical similarity of the target and source substances, the target substance is expected to exhibit a similar ecotoxicological profile. Therefore, it can be concluded that propylene dinonanoate (CAS 41395-83-9) will not cause short-term effects to aquatic invertebrates up to the limit of water solubility.