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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2018-07-23 to 2018-09-14
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
2014
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
flask method
Key result
Water solubility:
189 mg/L
Conc. based on:
test mat.
Incubation duration:
> 24 - <= 72 h
Temp.:
20 °C
pH:
4.6
Remarks on result:
other: No Tyndall-effect was observed for any of the centrifuged samples.

Validity criteria:

The study was performed based on OECD Guideline 105 for Testing of Chemicals (1995) and Council Regulation (EC) No. 260/2014, Method A.6. The validity criteria were fulfilled:

- The concentration measured at each sampling time did not differ for more than 15%.

- Temperatures were kept constant within ± 0.5 °C.

Water solubility results at 20°C:

Preincubation time

Replicate No.

Test item [mg/L]

Concentration

Mean

24 h

1

192

190

2

188

48 h

1

186

188

2

189

72h

1

190

189

2

188

Mean (24 – 72h)

 

 

189

Deviation [%] (24 – 72h)

1.0

The analytical method (HPLC-DAD, external standard) for the determination of the test item was validated and tested with satisfactory results in regard to linearity, accuracy, precision and specificity.

Conclusions:
The solubility of the test item was determined at 20 ± 0.5°C to be 189 g/L (pH 4.6) for the samples with pre-incubation times of 24, 48 and 72 h.

Description of key information

The solubility of the test item was determined at 20 ± 0.5°C to be 189 g/L (pH 4.6) for the samples with pre-incubation times of 24, 48 and 72 h.

Key value for chemical safety assessment

Water solubility:
189 g/L
at the temperature of:
20 °C

Additional information