2-ethoxy-2-oxoethyl ethyl methylenemalonate

Toxicity to aquatic algae and cyanobacteria

Link to relevant study record(s)

Reference

Endpoint:

toxicity to aquatic algae and cyanobacteria

Type of information:

(Q)SAR

Adequacy of study:

weight of evidence

Study period:

December 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Qualifier:

according to guideline

Guideline:

OECD Guideline 201 (Alga, Growth Inhibition Test)

Deviations:

no

GLP compliance:

not specified

Test organisms (species):

Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)

Test type:

static

Water media type:

freshwater

Total exposure duration:

72 h

Duration:

72 h

Dose descriptor:

EC50

Effect conc.:

102.32 mg/L

Nominal / measured:

estimated

Conc. based on:

not specified

Basis for effect:

growth rate

The estimated value for Ethyl Ethoxycarbonylmethyl 2-methylidenepropanedioate after applying the ProtoQSAR model for acute aquatic toxicity in algae was 102.32 mg/L. Furthermore, the compound falls inside the applicability domain of the model.

Conclusions:

PQSAR model for acute aquatic toxicity in algae estimated for Ethyl Ethoxycarbonylmethyl 2-methylidenepropanedioate an acute 72h EC50 to algae of 102.32 mg/L. The prediction, falls inside the applicability domain of the model and is considered reliable. Furthermore, and based on the Globally Harmonized System of Classification and Labelling (CLP/GHS) , the test compound is considerd non-toxic / non-harmful. 102.32mg/L > 100.

Executive summary:

Regulatory purpose: This study was designed to generate estimated in silico (nontesting) data for acute aquatic toxicity in algae for Ethyl Ethoxycarbonylmethyl 2-methylidenepropanedioate to be used in the regulatory framework of REACH. EC50 = 102.32mg/L

On the basis of EC 50 value it is concluded that this test chemical is considered to be not classified according to CLP classification criteria.

Description of key information

The acute aquatic toxicity in algae (EC50; 72 hours) (OECD 201) of Ethyl Ethoxycarbonylmethyl 2-methylidenepropanedioate was estimated using the PQSAR QSAr model. The estimated value was 102.32 mg/L. The prediction, falls inside the applicability domain of the model and is considered reliable. Furthermore, and based on the Globally Harmonized System of Classification and Labelling (CLP/GHS) , the test compound is considerd non-toxic / non-harmful. 102.32mg/L > 100. On the basis of EC 50 value it is concluded that this test chemical is considered to be not classified according to CLP classification criteria.

Key value for chemical safety assessment

EC50 for freshwater algae:

102.32 mg/L