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EC number: 701-173-1 | CAS number: -
The test substance was stable in the respective carriers.
Excretion, retention and tissue concentrations after dermal application of 14C-MDI:
Table 1: Mean excretion and retention of radioactivity after a single dermal administration of 14C-MDI (% of the radioactivity administered).
nominal dose [mg/cm2]
sacrifice time [h]
actual dose [mg/cm2]
skin (application site)
In all groups, the largest proportion of radioactivity was recovered from the dressing and the skin of the application site. The amount of radioactivity absorbed (including excreta, cage wash, tissues/organs and carcass) increased in time, but remained below 1% at all dose levels. Excretion occured via urine and feces. In similar amounts after 8 and 24h, but to a higher extend in feces after 120h. The radioactivity absorbed was distributed in all organs and tissues. Due to the limited dermal absorption, concentrations of radioactivity in organs and tissues analyzed were considerably below 1 µg Eq/g (except for carcass). Levels of tissue radioactivity were comparable at 8 and 24 h and declined until 120 h after application with highest levels generally being found in carcass, thyroid, muscle, plasma and liver (not shown in table).
Excretion, retention and tissue concentrations after intradermal application of 14C-MDI:
Table 2: Mean excretion and retention of radioactivity after a single intradermal administration of 14C-MDI (% of the radioactivity administered).
The largest proportion of radioactivity was found at the application site. The amount of radioactivity absorbed (including excreta, cage wash, tissues/organs and carcass) during the 120 h observation period amounted to 25.87 % of the dose applied. Excretion occurred mainly via the feces and concentrations of radioactivity in organs and tissues were rather low being below 1 µg Eq/g.
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