Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-173-1 | CAS number: -
The test substance is covered by the category approach of methylenediphenyl diisocyanates (MDI). Hence, data of the category substances can be used to cover this endpoint. The read-across category justification document is attached in IUCLID section 13. It is important to note that the MDI category approach for read-across of environmental and human hazards between the MDI substances belonging to the MDI category is work in progress under REACH. Therefore the read-across document should be considered a draft.
Due to the transient existence of MDI substances in the environment, only estimated values for water solubility, octanol-water partition coefficient (log Kow), soil adsorption coefficient (log Koc), and other inter-media partitioning parameters can be determined; and these numbers have little scientific value or relevance. This has been demonstrated by West (2008) for Toluenediisocyanate (TDI), which is similar to the MDI substances in structure and reactivity. A sensitivity analysis of the Level III fugacity model outputs for TDI showed that wide variation in model inputs such as water solubility and log Kow had negligible impact on the predicted environmental distribution and inter-media transport of such a reactive substance. This modeling analysis showed that, regardless of whether TDI (or in this case, MDI substances) are emitted directly to air, water, or soil, > 99.5% of the emission will remain and be degraded within the compartment to which emissions were made. Hence, the transport and distribution of the MDI substances are governed by their reactivity in environmental media, and properties such as water solubility, log Kow, and soil adsorption coefficient are of no real value and cannot be determined properly. No accumulation or inter-media exchange of the MDI substances is expected in the environment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again