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EC number: 701-173-1 | CAS number: -
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 08/10/2010 – 28/02/2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- effusion method: by loss of weight or by trapping vaporisate
- Temp.:
- 25 °C
- Vapour pressure:
- 0.002 Pa
- Temp.:
- 20 °C
- Vapour pressure:
- 0.001 Pa
- Conclusions:
- Vapour pressure at 20 °C: 8.41 * 10-04 Pa
Vapour pressure at 25 °C: 1.56 * 10-03 Pa - Executive summary:
The vapour pressure of HPU8: MDI/1,3-BD/DEG/PG was determined following EU A.4 by the effusion method (weight loss). For the test item HPU8: MDI/1,3-BD/DEG/PG, the following vapour pressures at 20 °C and at 25 °C were calculated from the regression equation:
Vapour pressure at 20 °C: 8.41* 10-04Pa
Vapour pressure at 25 °C: 1.56 * 10-03Pa
Reference
Vapour pressure at 20 °C: 8.41 * 10-04Pa
Vapour pressure at 25 °C: 1.56 * 10-03Pa
Description of key information
The experimental method used at Chilworth Technology Ltd. for vapour pressure determination was not suitable and the recommended ranges were inappropriate. Therefore, the study from Chilworth Technology Ltd., is considered to be Klimisch 2 reliability rating and it must be ignored.
The following estimated vapour pressures at 20°C and at 25°C were calculated from the regression equation:
Vapour pressure at 20 °C: 8.41 * 10E-4 Pa
Vapour pressure at 25 °C: 1.56 * 10E-3 Pa
Key value for chemical safety assessment
- Vapour pressure:
- 0.001 Pa
- at the temperature of:
- 20 °C
Additional information
Two studies are available on determination of vapour pressure of MDI/1,3-BD/DEG/PGI. In the initial study, the experimental method used at Chilworth Technology Ltd. for the test substance, vapour pressure determination was not considered suitable and the recommended range of 10E+2 to 10E+5 Pa was inappropriate for MDI/1,3-BD/DEG/PGI.
Therefore, while the report from Chilworth Technology Ltd., (Report no. GLP102942AR1V1/09), is considered to be Klimisch 2 reliability rating it must be ignored. The second study carried out at LAUS with the suitable method for this type of substance and the following vapour pressures are achieved:
Vapour pressure at 20 °C: 8.41 * 10E-4 Pa
Vapour pressure at 25 °C: 1.56 * 10E-3 Pa
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