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Toxicological information

Genetic toxicity: in vivo

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Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
Scientific Opinion on the Safety Evaluation of the Substance, Trimethyl trimellitate, CAS No. 2459-10-1, for Use in Food Contact Materials
Author:
EFSA
Year:
2011
Bibliographic source:
EFSA Journal 2011; 9(2): 1997

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
Deviations:
not specified
GLP compliance:
not specified
Type of assay:
mammalian erythrocyte micronucleus test

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid

Test animals

Species:
mouse
Strain:
not specified
Sex:
male/female

Results and discussion

Test results
Sex:
male/female
Genotoxicity:
negative
Toxicity:
no effects

Applicant's summary and conclusion

Conclusions:
No toxicity nor decrease in the ratio of polychromatic erythroctes were seen up to the maximum recommended dose of 2000 g/kg bw.
Executive summary:

A mammalian erythrocyte micronucleus test has been conducted in mice. No toxicity nor decrease in the ratio of polychromatic erythroctes were seen up to the maximum recommended dose of 2000 g/kg bw.