Registration Dossier
Registration Dossier
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EC number: 219-547-3 | CAS number: 2459-10-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
Data source
Reference
- Reference Type:
- grey literature
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPP 81-1 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Trimethyl benzene-1,2,4-tricarboxylate
- EC Number:
- 219-547-3
- EC Name:
- Trimethyl benzene-1,2,4-tricarboxylate
- Cas Number:
- 2459-10-1
- Molecular formula:
- C12H12O6
- IUPAC Name:
- 1,2,4-trimethyl benzene-1,2,4-tricarboxylate
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: ChR-CD
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- IN-LIFE DATES: From: 1980-05-14 To: 1980-08-14
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 10, 11, 12 and 14 g/kg bw
- No. of animals per sex per dose:
- 10 males/dose
- Control animals:
- no
- Statistics:
- Probit analysis using the methods of Finney
Results and discussion
- Preliminary study:
- Yes
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 12 232 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 11 429 - < 13 555
- Mortality:
- 10,000 mg/kg bw - 0% mortality
11,000 mg/kg bw - 40% mortatlity
12,000 mg/kg bw - 40% mortality
14,000 mg/kg bw - 80% mortality - Clinical signs:
- other: Salivation, stained and wet perineal are, stained face and weakness observed at most dose levels
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute oral median lethal dose (LD50) in the rat was determined to be 12232 mg/kg bw
- Executive summary:
The acute oral median lethal dose (LD50) in the rat was determined to be 12232 mg/kg bw
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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