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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods

Data source

Reference
Reference Type:
grey literature
Title:
Unnamed
Year:
1980
Report Date:
1980

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
EPA OPP 81-1 (Acute Oral Toxicity)
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid

Test animals

Species:
rat
Strain:
other: ChR-CD
Sex:
male
Details on test animals and environmental conditions:
IN-LIFE DATES: From: 1980-05-14 To: 1980-08-14

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Doses:
10, 11, 12 and 14 g/kg bw
No. of animals per sex per dose:
10 males/dose
Control animals:
no
Statistics:
Probit analysis using the methods of Finney

Results and discussion

Preliminary study:
Yes
Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
12 232 mg/kg bw
Based on:
test mat.
95% CL:
> 11 429 - < 13 555
Mortality:
10,000 mg/kg bw - 0% mortality
11,000 mg/kg bw - 40% mortatlity
12,000 mg/kg bw - 40% mortality
14,000 mg/kg bw - 80% mortality
Clinical signs:
Salivation, stained and wet perineal are, stained face and weakness observed at most dose levels
Body weight:
Moderate weight loss observed at most dose levels

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The acute oral median lethal dose (LD50) in the rat was determined to be 12232 mg/kg bw
Executive summary:

The acute oral median lethal dose (LD50) in the rat was determined to be 12232 mg/kg bw