Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 219-547-3 | CAS number: 2459-10-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption, other
- Remarks:
- in silico
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- key study
- Study period:
- April 18, 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- See the attached justification.
Data source
Referenceopen allclose all
- Reference Type:
- other: software
- Title:
- IH SkinPerm v2.04
- Author:
- AIHA Exposure Assessment Strategies Committee (EASC) and the Dermal Project Team (DPT) in collaboration with Wil ten Berg
- Year:
- 2 017
- Bibliographic source:
- Tibaldi, R., ten Berge, W., Drolet, D.. IH SkinPerm v2.0 Reference Manual. https://www.aiha.org/get-involved/VolunteerGroups/Documents/IH_SkinPerm_Manual_May_2017.pdf
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Guideline:
- other: ECHA Guidance on information requirements and chemical safety assessment - Chapter R.06: QSARs and grouping of chemicals
- Principles of method if other than guideline:
- See the justification for type of information.
Test material
- Reference substance name:
- Trimethyl benzene-1,2,4-tricarboxylate
- EC Number:
- 219-547-3
- EC Name:
- Trimethyl benzene-1,2,4-tricarboxylate
- Cas Number:
- 2459-10-1
- Molecular formula:
- C12H12O6
- IUPAC Name:
- 1,2,4-trimethyl benzene-1,2,4-tricarboxylate
Constituent 1
Results and discussion
Percutaneous absorption
- Time point:
- 2 h
- Dose:
- Deposition dose: 6060 mg
- Parameter:
- rate
- Absorption:
- <= 0.001 mg cm-2 h-1
Any other information on results incl. tables
DATA INPUT
Substance
EC name: trimethyl benzene-1,2,4-tricarboxylate
CAS number: 2459-10-1
Molecular weight: 252.22
Temperature: 25°C
Vapour Pressure: 0.0033 Pa
Water solubility: 1110 mg/L
Log Kow (skin, pH= 5.5): 1.96
Density: 1263 mg/cm3
Melting Point: 25°C
Scenario parameters
Instantaneous deposition
Deposition dose*: 6062 mg
Affected skin area**: 1000 cm2
Maximum skin adherence**: 1.5 mg/cm2
Thickness of stagnant air***: 1 cm
Weight fraction: 1
Timing parameters
Start deposition: 0 hr
End time observation: 2 hr
Report parameters
Calculationintervals/hours: 7200
Report intervals/hours: 120
* Approximately 2 mL of a liquid having a viscosity similar to water will practically wet the palms of two hands (ca. 420 cm2). So 4.8 mL will wet all the skin surface of both hands. It is reasonably expected more liquid will be excess and wash/fall off.
** Estimated skin surface of two hands of an adult.
*** Nude skin.
RESULTS
Fraction absorbed: 0.098%
Amount absorbed: 5.95 mg
Lag time stratum corneum:74.6 min.
Max. derm. abs.: 0.00149 mg/cm2/hr
Max. derm. abs. for 2000 cm2in 1 hour (from liquid): 2.99 mg
Dermal/Respiratory uptake ratio (from airborne vapour): R= 1.25
R= RX/X
RX: total dermal absorption by dermal exposure to airborne vapour
X: total inhalation absorption from airborne vapour
Assuming that Fully Respiratory Protection provides 100% efficiency
Protection from respirator = 100*X/(RX+X)= 100/(R+1) = 100/2.25 = 44.4%
protection against overexposure to the substance in the form of vapour due to dermal vapour absorption over whole body surface.
Applicant's summary and conclusion
- Conclusions:
- The dermal absorption of trimethyl benzene-1,2,4-tricarboxylate leads to the following results, obtained using the SkinPerm v2.04 model according to the input data:
Fraction absorbed: 0.098%
Amount absorbed: 5.95 mg
Lag time stratum corneum: 74.6 min.
Max. derm. abs.: 0.0149 mg/cm2/hr
Max. derm. abs. for 2000 cm2 in 1 hour (from liquid): 2.99 mg
Dermal/Respiratory uptake ratio (from airborne vapour): R= 1.25 - Executive summary:
In-silico evaluation of dermal absorption shows that after 2 hours only ca. 6 mg. of deposited substance are absorbed within viable epidermis and therefore could enter in systemic circulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.