Registration Dossier
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EC number: 810-753-4 | CAS number: 1374639-78-7
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Feb - June 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7950 (Vapor Pressure)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- GLP compliance:
- yes
- Type of method:
- effusion method: isothermal thermogravimetry
- Key result
- Test no.:
- #1
- Temp.:
- ca. 20 °C
- Vapour pressure:
- < 0 Pa
- Key result
- Test no.:
- #2
- Temp.:
- ca. 25 °C
- Vapour pressure:
- < 0 Pa
- Executive summary:
The isothermal TGA effusion method was applied for the determination of the vapour pressure of LEE011-A3.
The vapour pressure (Pa) of the test substance at
20°C (293K) was < 8.4 × 10-7
25°C (298K) was < 2.2 × 10 -6
Reference
A log p versus 1/T curve could not be obtained for the test substance in the range of 170°C and 190°C. The coefficient of correlation (r) was < 0.99. It indicated that the weight loss was obtained due to reaction and/or decomposition of the test substance. With the vapour pressure test the test substance was kept at elevated temperature for much longer intervals than during the melting and boiling temperature study. Reaction and/or decomposition consequently occurred at lower temperatures which was also observed by discoloration of the test substance from beige to grey/brown. Based on the results obtained the weight loss of the test substance was compared with the results of chrysene obtained by the validation test.
The weight loss of the test substance at 170°C, 180°C, 190°C and 200°C was lower than the weight loss of chrysene at the same temperatures. According to this the vapour pressure of the test substance was determined to be lower than that of chrysene.
Description of key information
The isothermal TGA effusion method was applied for the determination of the vapour pressure of LEE011-A3.
The vapour pressure (Pa) of the test substance at
20°C (293K) was < 8.4 × 10-7
25°C (298K) was < 2.2 × 10-6
Key value for chemical safety assessment
- Vapour pressure:
- 0 Pa
- at the temperature of:
- 20 °C
Additional information
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