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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

Nominal concentrations: 96-h LL50 (reported as “LC50” in the report) >1,000 mg/L. This is equivalent to 96-h LL0 (reported as “NOEC” in the report) of 1,000 mg/L.
Test results reported in the study as “lethal concentrations” are reported in this summary as “lethal loading rate”, because test results are based on WAF loading rates.

Key value for chemical safety assessment

LC50 for freshwater fish:
1 000 mg/L
LC50 for marine water fish:
10 000 mg/L

Additional information

In the key study, the acute toxicity of the water accommodated fraction (WAF) of 100, 300, and 1,000 mg/L mixtures of the test material and water to the fathead minnow, Pimephales promelas, was investigated during a study conducted at the Envirosystems Division of Resource Analysts, Inc. and T.R. Wilbury Laboratories, Inc.

The test, which was designed to determine the toxicity of the WAFs of test substance, was performed from August 6 to 10, 1991

and was conducted according to the OECD Guideline 203 (Fish, Acute Toxicity Test) and GLP.

This study is presented as the key information as the reliability rating for this study is 1, according to the criteria of Klimisch, 1997. This study was conducted under freshwater conditions which is the preferred system and was also tested at the lower concentrations than the supporting study and therefore is considered the most reliable study.

Marine conditions:

- The Nicholson R.B. and Breteler R.J. 1986 study (Springborn Bionomics, Inc. report number: BW-86-04-1982) was not considered the key study as it was conducted less recently than the above key study and also it was conducted under marine conditions which are not the preferred conditions for this endpoint. However for chemical safety assessment purposes, the LC50 from this study will satisfactory fulfil the marine key study endpoint.

The study was conducted according to the OECD Guideline 203 (Fish, Acute Toxicity Test) and GLP. The study was therefore considered to have a reliability rating of 1, according to the criteria of Klimisch, 1997.

Based on the results the 100% WSF (10 g/L) of Test Material is not toxic to ≥ 50% of the test organism population and was therefore not subject to Tier II definitive testing.