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EC number: 205-758-8
CAS number: 150-38-9
Table 1: Mortalities of rats after oral
application of Na4EDTA
1: Mortalities of rats after oral application
In an acute oral toxicity study performed
with the read-across substance disodium hydrogen EDTA (CAS 139 -33 -3)
by BASF (1973), single doses of 2500, 3200, 4000, 5000 and 6400 mg/kg bw
Na2EDTA were administered by gavage to male and female rats as 30%
solution in carboxymethyl cellulose solution. The dose groups consisted
of 5 males and 5 females each and the animals were observed for 7 days.
The LD50 was found to be 2800 mg/kg bw. Clinical symptoms were
accelerated respiration, squatting posture, contaminated fur,
intermittened respiration, reluctance to move. Autopsy of animals which
died revealed dilatation of the heart and stomach as well as diarrhoea
like content in the gut, congestion of the liver and degeneration of the
kidney. The animals which were sacrificed showed no abnormalities during
necropsy. For reasons of a conservative (worst case) assessment approach
data these data were not used for risk assessment and classification.
An LD50 in rats of >=
4000 - <= 8000 mg/kg bw was determined for the target
substance trisodium EDTA (cited
in CIR, 2002). However, as no further details on the study design
were available, this information was not considered for
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