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Diss Factsheets
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EC number: 202-443-7 | CAS number: 95-71-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian cell study: DNA damage and/or repair
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 993
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Unscheduled DNA synthesis via induction ornithin decarboxylase
Single strand scission determined by an alkaline elution method. - GLP compliance:
- not specified
- Type of assay:
- unscheduled DNA synthesis
Test material
- Reference substance name:
- 2-methylhydroquinone
- EC Number:
- 202-443-7
- EC Name:
- 2-methylhydroquinone
- Cas Number:
- 95-71-6
- Molecular formula:
- C7H8O2
- IUPAC Name:
- 2-methylbenzene-1,4-diol
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344/DuCrj
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- 99% methylhydroquinone (no vehicle)
- Duration of treatment / exposure:
- once
- Frequency of treatment:
- once
- Post exposure period:
- 48 h
Doses / concentrationsopen allclose all
- Dose / conc.:
- 0 mg/kg bw/day (nominal)
- Dose / conc.:
- 90 mg/kg bw/day (nominal)
- Dose / conc.:
- 200 mg/kg bw/day (nominal)
- Dose / conc.:
- 250 mg/kg bw/day (nominal)
- Dose / conc.:
- 300 mg/kg bw/day (nominal)
- No. of animals per sex per dose:
- not given
- Control animals:
- yes
- Positive control(s):
- MNNG (N-methyl-N'-nitro-N-nitrosoguanidine)
Examinations
- Tissues and cell types examined:
- pyloric mucosa
- Evaluation criteria:
- Ornithine decarboxylase (ODC) and replicative DNA synthesis (RDS) as markers of tumor promotion,
DNA single strand scission and unscheduled DNA synthesis (UDS) as markers of tumor initiation.
Results and discussion
Test results
- Key result
- Sex:
- male
- Genotoxicity:
- positive
- Toxicity:
- yes
- Remarks:
- low effects at 200 mg/kg bw
- Vehicle controls validity:
- not specified
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- Methylhydroquinone showed very weak tumor-promoting activities and some tumor-initiating activities in the pyloric mucosa of rat stomach.
- Executive summary:
In an in vivo study, tumor initiation and tumor promotion were investigated using methylhydroquinone as test item in the pyloric mucosa of male F344 rats. Methylhydroquinone showed very weak tumor-promoting activities and some tumor-initiating activities in the pyloric mucosa of rat stomach.
Ornithine decarboxylase (ODC) and replicative DNA synthesis (RDS) were used as markers of tumor promotion and DNA single strand scission and unscheduled DNA synthesis (UDS) as markers of tumor initiation.
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