Registration Dossier
Registration Dossier
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EC number: 947-962-6 | CAS number: -
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 05/03/2018-15/03/2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Extract obtained from defatted powder of Theobroma cacao (Malvaceae) by extraction with ethanol
- EC Number:
- 947-375-5
- IUPAC Name:
- Extract obtained from defatted powder of Theobroma cacao (Malvaceae) by extraction with ethanol
- Test material form:
- other: liquid pasty
Constituent 1
- Specific details on test material used for the study:
- Name : C03505 CACAO EXTRAIT/PG Nr 5
Structural form : Multi-constituent
CAS No : N/A
EC No : N/A
Reference : C03505
Batch No : 100507204
Purity (% w/w) PG = 79.3% w/w
Expiry date : 21/11/18
Provided by : Sponsor
Test item Internal No : RRCo-000139_0001
Test item description : C03505 CACAO EXTRAIT/PG Nr 5
Reception date : 28/11/17
Reception condition : Cooled
track item : TI_0007125
Received quantity (Container + content) : 32,6477 g
Storage : Test item has been stored according to MSDS recommendations:
temperature - 20 °C
brightness darkness
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficientopen allclose all
- Key result
- Type:
- log Pow
- Partition coefficient:
- >= -3.79 - <= 0.13
- Temp.:
- 40 °C
- pH:
- ca. 6
- Key result
- Type:
- log Pow
- Partition coefficient:
- >= -4.85 - <= 0.14
- Temp.:
- 40 °C
- pH:
- ca. 6
Applicant's summary and conclusion
- Conclusions:
- The estimated Partition Coefficient (log Pow) logarithm of the test substance was < 0 (estimate in the range -4.32* to 0.14* using extrapolation of the linear regression).
- Executive summary:
The partition coefficient study was performed according to OECD 107 guideline.
The estimated Partition Coefficient (log Pow) logarithm of the test substance was < 0 (estimate in the range -4.32* to 0.14* using extrapolation of the linear regression).
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