Registration Dossier
Registration Dossier
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EC number: 602-927-1 | CAS number: 123312-89-0
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Remarks:
- general pharmacological study
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 10 May 1995 to 20 Jul 1995
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: The guidelines issued by the Ministry of Agriculture, Forestry and Fisheries of Japan (59 Nohsan No. 4200, 1985)
- GLP compliance:
- yes
- Type of method:
- in vitro
- Endpoint addressed:
- neurotoxicity
Test material
- Reference substance name:
- 6-methyl-4-[(E)-[(pyridin-3-yl)methylidene]amino]-2,3,4,5-tetrahydro-1,2,4-triazin-3-one
- EC Number:
- 602-927-1
- Cas Number:
- 123312-89-0
- Molecular formula:
- C10H11N5O
- IUPAC Name:
- 6-methyl-4-[(E)-[(pyridin-3-yl)methylidene]amino]-2,3,4,5-tetrahydro-1,2,4-triazin-3-one
- Test material form:
- solid: particulate/powder
Constituent 1
Results and discussion
Any other information on results incl. tables
No effect was seen on the acetylcholine-, histamine- and Ba++ - induced contractions on the isolated ileum.
Applicant's summary and conclusion
- Conclusions:
- In this study, the test substance did not affect contractions of Guinea pig ileum preparations in vitro.
- Executive summary:
In this study effects of the test substance on the autonomic nervous system were studiedin vitropreparations of Guinea pig ileum at concentrations of E-4, E-5, E-6, E-7 g/mL. The test substance was dissolved in dimethylsufloxide.
Measurements were performed on preparations of Guinea pig ileum. Contractile responses were induced by acetylcholine, histamine, or barium chloride (BaCl2). After a stable response of each agonist was obtained, each agonist was repeatedly added in the presence of vehicle or test substance with about 5 minutes incubation.
No effect was seen on the acetylcholine-, histamine- and Ba++ - induced contractions on the isolated ileum.
In conclusion, the test substance did not affect contractions of Guinea pig ileum preparations in vitro.
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