Registration Dossier
Registration Dossier
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EC number: 217-315-6 | CAS number: 1809-14-9
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation/corrosion
Dioctyl phosphonate was tested for its skin irritation potential with an in vitro test according to OECD TG 439 Reconstructed human epidermis model. The relative mean viability of the test item treated tissues was 53 % after 15 minutes exposure period and 42 hours of post-exposure incubation period. No classification for skin irritation of Dioctyl phosphonate is required according to the CLP Regulation (EC.n.1272/2008).
Eye irritation
Dioctyl phosphonate was tested for its eye irritation potential with an in vitro test according to OECD TG 492 Reconstructed human Cornea-like Epithelium (RhCE) test method. After 28 minutes exposure followed by product washing and a post incubation of 120 minutes a residual cell viability (mean of two replicates) of 10.7 % has been quantified for test item. Considering the results of in vitro tests for skin and eye irritation, the structure of the molecule and its pH in water (3.9), Dioctyl phosphonate is classified H319 (eye irritant category 2) according to the CLP Regulation (EC.n.1272/2008).
Justification for classification or non-classification
According to the OECD TG 439 (EpiSkinTM/MTT Method) the test item is classified not irritant to skin if the mean relative viability is higher than 50% according to the CLP Regulation (EC n.1272/2008). Dioctyl phosphonate was tested for skin irritation according to OECD TG 439: the mean cell viability of the test item treated tissues was 53 % and therefore no classification for skin irritation/corrosion is required according to the CLP Regulation (EC n.1272/2008).
According to the OECD TG 492, the test item is classified not irritant to eyes if the mean relative viability is higher than 60 % according to the CLP Regulation (EC n.1272/2008). Dioctyl phosphonate was tested for eye irritation according to OECD TG 492: the mean cell viability of the test item treated tissues was 10.7 %. The EpiOcularTM Eye Irritation Test does not allow discrimination between eye irritation/reversible effects on the eye (Category 2) and serious eye damage/irreversible effects on the eye (Category 1). Based on weight of evidence approach with the information available from different tests on this substance (it is not skin irritant, the pH in aqueous solution is 3.9 , no alert was found for its potential irritation/corrosion by QSAR toolbox and it was positive in the test eye irritation/eye damage according to OECD TG 492), Dioctyl phosphonate is classified as eye irritant (H319, cat.2) according to the CLP Regulation (EC n.1272/2008).
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